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4 Cards in this Set
- Front
- Back
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Describe what happens at the neuromuscular junction to cause depolarisation of the post-synaptic membrane.
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See flow diagram.
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Describe the molecular mechanism that initiates muscle contraction/ Describe events leading up to muscle contraction.
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AP travels down T-tubule
DHP receptor on T-tubule transmits this info to Ryanodine receptor on surface of sarcoplasmic reticulum. Ryrs causes Ca2+ to be sequestered from SR and Ca2+ leaves through Ryrs and released from terminal cisternae of SR and then binds to troponin... (see L06) |
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What is myesthenia gravis and what causes it?
How can we treat it? |
Myesthenia gravis is when there is muscle weakness during sustained activity and is caused by an autoimmune disorder whereby the nAchR are damaged so there are less of them.
It can be treated by AChE inhibitors such as neostigmine as they prolong the time ACh lingers so there is an increased chance of binding to receptors for muscle contraction. |
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What are the signs and symptoms of myesthenia gravis?
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- Droopy eyelid (ptosis)
- Inability to smile - Saggy face (as we need lots of muscles to keep face) |
