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16 Cards in this Set
- Front
- Back
Naloxone
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Opiate. Used for quitting opiates. mu,delta, kappa antagonist
Reverses all opioid fx. Selective for mu and kappa, bit for delta. |
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Morphine
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Opiate. Acts on mu, little on kappa. Decreases Substance P release. Use with IV - high 1st pass. Used better for chronic pain. Causes mental clouding + smooth muscle constriction symptoms: constipation, decreased CO2 detection, decreased respiratory rate/volume, miosis, decreases cough reflex. Do not use on pregnancy, gallbladder pain, renal colic pain, head trauma, or asthma pts.
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Codeine
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Opiate. Used as cough suppressant. Less effective than morphine as analgesic, better antitussive. Used orally. Inhibited by Paroxentine, an SSRI.
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Heroin
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Opiate. Converted to Morphine in the body, rapid onset
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Meperidine
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Opiate Demerol. Less constipation/miosis than morphine. No antitussive fx. Abused by health care pros. Do NOT mix with MAOIs, Amphetamines.
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Etorphine
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Opiate. Binds to all three, mu, kappa and delta receptors equally
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Pentazocine
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Opiate. For ppl with chronic pain/substance abuse history. Acts on kappa, weak mu.
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Buprenorphine
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Opiate. Partial agonist for μ-receptor, displaces morphine.
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Prednisone, Hydrocortisone
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Steroid Analgesics - Inhibit arachidonic acid (AA) production, some COX path inhibition.
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NSAID MOA
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Drug class inhibits cyclooxygenase enzymes = aka blocks COX 1&2 Pathways = block production of prostaglandins and thromboxone from arachidonic acid (AA). Prostaglandins are mainly pain signals, thromboxane forms clots.
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NSAID Effects
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Anesthetic, Anti-inflammatory, anti-pyretic. Uricosuric effect - blocks tubular reabsorption and secretion of uric acids.
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Opiate MOA
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Activate mu (μ), delta (δ) and kappa (κ) opioid receptors in the CNS, mainly in the dorsal horn of spinal cord on nociceptive and primary afferent neurons.
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Rofecoxib, Celecoxib
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NSAIDS Vioxx and Celebrex. COX-2 Inhibitors, linked with CV events.
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Acetylsalicylic acid
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NSAID prototype Aspirin. Antiplatelet, antipyretic and analgesic. Blood thinner. Side fx - Gastric intolerance, bleeding. Tinnitus = Toxicity sign.
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Acetaminophen
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Tylenol. NOT NSAID. Not anti-inflammatory. Analgesic and anti-pyretic effect. Hepatotoxic. Use N-acetylcysteine for overdose treatment.
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N-acetylcysteine
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Acetaminophen overdose treatment. Provides exogenous SH groups so the toxin can attack something else.
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