• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/16

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

16 Cards in this Set

  • Front
  • Back
Naloxone
Opiate. Used for quitting opiates. mu,delta, kappa antagonist
Reverses all opioid fx. Selective for mu and kappa, bit for delta.
Morphine
Opiate. Acts on mu, little on kappa. Decreases Substance P release. Use with IV - high 1st pass. Used better for chronic pain. Causes mental clouding + smooth muscle constriction symptoms: constipation, decreased CO2 detection, decreased respiratory rate/volume, miosis, decreases cough reflex. Do not use on pregnancy, gallbladder pain, renal colic pain, head trauma, or asthma pts.
Codeine
Opiate. Used as cough suppressant. Less effective than morphine as analgesic, better antitussive. Used orally. Inhibited by Paroxentine, an SSRI.
Heroin
Opiate. Converted to Morphine in the body, rapid onset
Meperidine
Opiate Demerol. Less constipation/miosis than morphine. No antitussive fx. Abused by health care pros. Do NOT mix with MAOIs, Amphetamines.
Etorphine
Opiate. Binds to all three, mu, kappa and delta receptors equally
Pentazocine
Opiate. For ppl with chronic pain/substance abuse history. Acts on kappa, weak mu.
Buprenorphine
Opiate. Partial agonist for μ-receptor, displaces morphine.
Prednisone, Hydrocortisone
Steroid Analgesics - Inhibit arachidonic acid (AA) production, some COX path inhibition.
NSAID MOA
Drug class inhibits cyclooxygenase enzymes = aka blocks COX 1&2 Pathways = block production of prostaglandins and thromboxone from arachidonic acid (AA). Prostaglandins are mainly pain signals, thromboxane forms clots.
NSAID Effects
Anesthetic, Anti-inflammatory, anti-pyretic. Uricosuric effect - blocks tubular reabsorption and secretion of uric acids.
Opiate MOA
Activate mu (μ), delta (δ) and kappa (κ) opioid receptors in the CNS, mainly in the dorsal horn of spinal cord on nociceptive and primary afferent neurons.
Rofecoxib, Celecoxib
NSAIDS Vioxx and Celebrex. COX-2 Inhibitors, linked with CV events.
Acetylsalicylic acid
NSAID prototype Aspirin. Antiplatelet, antipyretic and analgesic. Blood thinner. Side fx - Gastric intolerance, bleeding. Tinnitus = Toxicity sign.
Acetaminophen
Tylenol. NOT NSAID. Not anti-inflammatory. Analgesic and anti-pyretic effect. Hepatotoxic. Use N-acetylcysteine for overdose treatment.
N-acetylcysteine
Acetaminophen overdose treatment. Provides exogenous SH groups so the toxin can attack something else.