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19 Cards in this Set

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  • Back
Name the type of receptors moderate agonists act on and give one example of a moderate agonist
mu and kappa receptors, codeine
What type of opiod analgesic stimulates kappa receptors but blocks me receptors?
mixed agonist-antagonist
Name the type of receptors that strong agonists act on, and give an example of a strong agonist.
mu and kappa receptors, example is morphine
Relief of pain without loss of consciousness is called____________
analgesia
Alkaloids from opium poppy seeds are called ___________
opiates
Natural and semisynthetic opiates and synthetic drugs with similar actions are called ______________
opiods
Name the 5 areas where opiod receptors are present
brainstem, medial thalamus, spinal cord, hypothalamus, and limbic system
What are the names for endogenous opiate-like substances released by the body to control pain under specific conditions?
Endorphins and enkephalins
Is an example of a mixed agonist-antagonist:
a-pentazocine
b-nalbuphine
c-butorphanal
d-all of the above
all of the above are mixed agonist-antagonists
what is an example of a drug that used used when someone takes takes too much codeine?
naloxone or nalrexone, both are opiod antagonists
Drugs that act on this receptor cause analgesia at a supraspinal level, euphoria, respiratory depression, and physical dependence.
a-kappa
b-sigma
c-mu
c- mu receptors
drugs that act on this type of receptor cause analgesia at the spinal level, miosis and sedation
a-kappa
b-sigma
c-mu
a- kappa receptors
drugs that act on this kind of receptor cause dyphoria, hallucinations, and cardiac stimulant actions
a-kappa
b-sigma
c-mu
c- sigma receptors
True or False: A person on morphine will have dialated eyes and be depressed
False, effects include miosis and euphoria, as well as pain tolerance, nausea, vomiting, depression of respiration and cough reflex, decrease in GI motility, release of histamines, and prolongation of labor.
Name 3 therapeutic uses of morphine.
Analgesia (pain relief), tx of diarrhea, and relief of cough
True or False:
Moderate and strong agonists have similar effects on the body?
True, however moderate agonists have less side effects
What is the difference in route of administration for strong and moderate agonists?
Strong- oral, IM, or IV
moderate- oral only
True or false: Naloxone is administered parentally and can cause a withdrawal syndrome in opiod addicts
true!
Endorphins interact with which type of receptor?
Mainly with the delta receptors