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20 Cards in this Set

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Normal thyroxine levels?

0.8-1.7mcg/dl
Normal thyroid stimulating hormone levels?
0.3-3.0microIU/ml
levothyroxine pregnancy category?
A (require 30-50% increase in dose during preganacy)
drugs that can induce hypothyroidism?
amiodarone, lithium, interferon
MOA hair loss hypothyrdoidism
both hypo and hyper thyroidism can cause increase in testosterone to DHT conversion leading to hair loss
What should be done if switching generic to brand?
Not all AB rated so should check s/sx and labs in 6-8 weeks
Dosing of levothyroxine for elderly?
0.5mcg/kg/day (but start at 12.5 to 25mcg/d and titrate)
Dosing for younger patients? (<50yoa)
1.7mcg/kg/day
Contraindications to thyroid medications?
acute mi, thyrotoxicosis, uncorrected adrenal insufficiency
levothyroxine iv to po conversion
1:2 (iv to PO)
thyroid USP place in therapy?
natural porcine derived med combo of t3 and t4; some feel better using it as is "natural"
liothyronine place in therapy?
short half life leading to erratic levels of t3; not recommended
Most common cause of hyperthyrodism
graves disease (autoimmune; tends to occur in females in 30 to 40s)
drugs that can cause hyperthyrodism
interferons, iodide, amiodarone
DOC for graves disease?
RAI-131 (radioactive iodine)
Drugs for treating hyperthyrodism?
PTU or methmazole
PTU drug class and moa?
thioamide; inhibit synthesis of thyroid hormones by blocking oxidation of iodine in thyroid gland and PTU also blocks peripheral conversion of t4 to t3
Side effects of PTU/methimazole?
gi upset, hepatitis, agranulocytosis
pregnancy and hyperthyrodisim tx?
PTU for trying to conceieve and first trimester, methimazole for 2nd and third trimester
Which thionamide for pregnancy?
PTU