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20 Cards in this Set
- Front
- Back
Normal thyroxine levels? |
0.8-1.7mcg/dl
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Normal thyroid stimulating hormone levels?
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0.3-3.0microIU/ml
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levothyroxine pregnancy category?
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A (require 30-50% increase in dose during preganacy)
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drugs that can induce hypothyroidism?
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amiodarone, lithium, interferon
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MOA hair loss hypothyrdoidism
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both hypo and hyper thyroidism can cause increase in testosterone to DHT conversion leading to hair loss
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What should be done if switching generic to brand?
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Not all AB rated so should check s/sx and labs in 6-8 weeks
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Dosing of levothyroxine for elderly?
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0.5mcg/kg/day (but start at 12.5 to 25mcg/d and titrate)
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Dosing for younger patients? (<50yoa)
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1.7mcg/kg/day
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Contraindications to thyroid medications?
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acute mi, thyrotoxicosis, uncorrected adrenal insufficiency
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levothyroxine iv to po conversion
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1:2 (iv to PO)
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thyroid USP place in therapy?
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natural porcine derived med combo of t3 and t4; some feel better using it as is "natural"
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liothyronine place in therapy?
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short half life leading to erratic levels of t3; not recommended
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Most common cause of hyperthyrodism
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graves disease (autoimmune; tends to occur in females in 30 to 40s)
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drugs that can cause hyperthyrodism
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interferons, iodide, amiodarone
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DOC for graves disease?
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RAI-131 (radioactive iodine)
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Drugs for treating hyperthyrodism?
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PTU or methmazole
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PTU drug class and moa?
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thioamide; inhibit synthesis of thyroid hormones by blocking oxidation of iodine in thyroid gland and PTU also blocks peripheral conversion of t4 to t3
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Side effects of PTU/methimazole?
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gi upset, hepatitis, agranulocytosis
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pregnancy and hyperthyrodisim tx?
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PTU for trying to conceieve and first trimester, methimazole for 2nd and third trimester
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Which thionamide for pregnancy?
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PTU
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