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24 Cards in this Set
- Front
- Back
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Gm + stain?
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purple/bluish
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Gm - stain?
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pink/redish
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MIC definition?
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lowest drug concentration that prevents microbial growth in 24 h
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Minimum bactericidal concentration?
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lowest drug concentration that reduces bacterial density by 99.9% in 24h
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Facts to consider when selecting a drug regimen?
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Site of infection
Severity of disease Patient characteristics (age, renal function, liver function, allergies, pregnancy, etc) Spectrum of drug activity Etiology of infection |
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Monitoring for Abx therapy effectiveness
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WBC, procal, esr, crp, fever, radiological findings, pain/inflammation, reduction in s/sx
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MOA of aminoglycosides?
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inhibit protein synthesis by binding the 30s subunit of the ribosome
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AG are concentration dependent or time dependent killing?
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dependent; have post antibiotic effect
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What is post antibiotic effect?
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continued suppression of growth when concentration is below MIC
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AGs blackbox warning?
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neurotoxicity (vertigo, ataxia) and nephrotoxicity
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AGs spectrum?
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mainly against gram - bacteria but can be used in synergy against staph and enterococcus
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Which AG has the broadest spectrum?
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amikacin
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How are AGs dosed?
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IBW unless ABW is less; use adj is ABW is >30% of IBW
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AG monitoring?
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peak/trough if conventional dosing, trough if extended interval. collect peak serum level (PSL) exactly 1 hr after start of infusion of 3rd dose (MDD)
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AG pregnancy category?
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D
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Neomycin dosing?
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prophylaxis GI surgery = 1g po tid w/ erythro
hepatic coma= 4-12g per day po (sanford) |
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Gentamicin/tobramycin multiple daily dosing/conventional dosing?
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2mg per kg load then 1.7mg per kg q8h
Peak 4-10mcg/ml and trough 1-2mcg/ml |
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Gentamicin/tobramycin once daily dosing?
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5.1mg per kg q24h (7mg/kg if critically ill)
peak - 16-24mcg/ml & trough <1mcg/ml |
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Amikacin multiple daily dosing?
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7.5mg per kg q12
peak 15-30mcg/ml & trough 5-10mcg/ml |
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Amikacin once daily dosing?
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15mg/kg q 24h
peak 56-64mcg/ml & trough <1mcg/ml |
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MOA of PCN?
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beta-lactams inhibit bacterial cell wall synthesis by binding to penicillin binding proteins (PBPs) which prevents the final transpepidation step of peptidoglycan synthesis in bacterial cell walls
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PCN concentration dependent or time dependent killing?
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time dependent
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AG bacteriostatic or bactericidal?
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bactericidal
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PCN bacteriostatic or bacteriocidal?
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bacteriocidal
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