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23 Cards in this Set
- Front
- Back
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Ampho B SE |
Hypokalemia
hypomagnesium nephrotox |
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How Ampho works
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binds ergosterol (cell membrane stuff)
fungicidal |
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Flucytosine
how work |
converted FU interferes fungal RNA
fungicidal |
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Azoles
how work |
decrease ergosterol (inhib cell wall)
fungistatis usually |
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Itraconazole points
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PO cap and PO soln not F equal
the cap needs gastric acid for F |
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Voriconazole points
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empty stomach
CI 3A4 substrates more activity Aspergillis, C glabrata, C krusei, Fusariim |
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Vori SE
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visual changes (careful night drive)
correct K, Ca, Mg prior to therapy monitor LFTs, electrolytes, vision hepatic metab so careful of MM |
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Posaconazole notes
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full meal
increase LFT |
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which azoles pH dependant absorb
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itroconazole and ketoconazole
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aspergillizs DOC
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A->V
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micafungin dosing candidemia vs esophageal candidias
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100mg IV daily
EC 150mg IV daily over 60 mins |
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audulafungin dosing
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EC 100mg day 1, 50 daily after
C 200day 1 then 100 daily |
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candins SE
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increase LFTs
very lil interactions, no renal adjust |
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how long tx a candida bloodstream infection
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2 wks...14 days FROM FIRST -ve CULTURE
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how long treat
oropharmngeal candidiasis esophageal |
oropharyngeal candidiasis]\
7-14 days E- 14-21 days -deeper so longer |
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what are viruss
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obligate intracellurlar parasites
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neuramidase inhibitors when and dose
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tx 75mg BID x 5 days
Prevention 75mg daily x 10days |
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Tamiflu SE
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comiting
rhinorrhea dyspepsia urti Rare- neuropsych - more in children |
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Zanamivir note
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Bronchospasm risk
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how likely is cross resistance w acyclovir and valacyclovir or famcyclovir
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very high
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shingles when should therapy start
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w/I 72 hours
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west nile virus
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nothing underlined
use acyclovir (meds don't really work tho) Prevention key |
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Gannciclovir BBW
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lots
Mylosupresscarcinogen teratogen |
