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26 Cards in this Set
- Front
- Back
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What are 4 drugs that cause gingival hyperplasia? |
(very dirty PC) Verapamil, Diltiazem, Phenytoin, Cyclosporine |
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for Digoxin, what kind of chronotrope or inotrope? |
Negative chronotrope (so it decrease HR) Positive ionotrope |
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Digoxin with other drugs interaction? |
HypoK, hypoMg, HyperCa : will increase the risk of digoxin toxicity |
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brand names for Amiodarone? |
- Cordarone - Pacerone - Nexterone |
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what is the t1/2 of Amiodarone? |
40-60 days |
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what kind of bag Amiodarone should be in? |
non-PVC container such as polyolefin or glass (Galaxy container) |
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Box warning of Amiodarone? |
- have to be in the hospital to initiate - pulmonary toxicity - liver toxicity - pro arrhythmic (exacerbation) |
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SE of Amiodarone? |
Hypotension, bradycardia, corneal micro deposits, dizziness, ataxia, N/V, constipation, tremor, |
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warning for Amiodarone? |
-More hypothyroidism than hyperthyroidism -inhibit peripheral conversion of T4 to T3 -optic neuropathy -photosensitivity (slate blue skin) |
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what do you need to do with Digoxin or Warfarin dose when taking with Amiodarone? |
decrease Digoxin dose by 50% decrease Warfarin dose by 30-50% |
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What are maximum doses of Simvastatin or Lovastatin when taking with Amiodarone? |
- Simvastatin: max 20mg/day - Lovastatin: max 40mg/day |
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Mnemonic for classification of Antiarrhythmic drugs? |
1a - (Police Department Question) Procainamide, Disopyramide, Quinidine 1b - (Liquored Man) Lidocaine, Mexiletine 1c - (For Peeing) Flecainide, Propafenone II - (Bee Bee) Beta Blockers III - (After Drinking Scotch in Dark) Amiodarone, Dronedarone, Sotalol, Ibutilide, Dofetilide IV - (Dirty Vehicle) Diltiazem, Verapamil |
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What is box warning for Procainamide? and it's SE? |
- fatal blood dyscrasias ( i.e. agranulocytosis) - DILE (20-30%) - side effects: Hypotension, rash |
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SE of Quinidine? |
- diarrhea, stomach cramping |
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SE of Flecainide? |
dizziness, visual disturbances |
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SE of Propanfenone? |
tase disturbance (metallic) dizziness, visual disturbances |
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What need to know about Dronedarone? |
- take with food - QT prolong, increase SCr - Pregnancy X |
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What need to know about Stalol? (Betapace) |
- CrCl 40-60 then decrease frequency (adj dose interval based on CrCl) - QT prolong directly relate to Sotalol conc. |
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What need to know about Ibutilide (Corvert)? |
- only injection - only can use twice |
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Dofetilide (Tykosyn) have REM program? |
Yes |
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Brand for Diltiazem? |
Cardizem Cartia Dilacor Dilt-CD Diltzac Tiazac Taztia |
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Brand for Verapamil? |
Calan Covera Verelan |
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Brand for Digoxin? (it has neg chronotrope - decrease HR) (has pos ionotrop) |
Digital Digox Lanoxin |
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therapeutic range of Digoxin in Arrhythmias? |
Afib: 0.8-2 ng/ml antidote: DigiFab |
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Toxicity of Digoxin? |
initial s/sx of toxicity are N/V, loss of appetite and bradycardia |
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what can increase digoxin toxicity? |
hypoK, hypoMg, hyperCa will increase the risk of digoxin toxicity (think of Digoxin and thiazide) |
