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20 Cards in this Set
- Front
- Back
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sulfonylureas
-1st generation (4) -2nd generation (3) -meglitinides (2) |
1st gen: acetohexamide, chlorpropamide, tolazamide, tolbutamide (CATT)
2nd gen: glipizide (Glucotrol), glyburide (DiaBeta, Micronas, Glynase), glimepiride (amaryl) meglitinides: repaglinide (Prandin), nateglinide (Starlix) |
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DM meds that can increase risk of hypoglycemia
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sulfonylureas, insulin
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metformin site and MOA
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hepatic, peripheral and intestinal: decreased gluconeogenesis, increased peripheral uptake of insulin, decreased intestinal absorption of glucose
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metformin counseling
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can decrease weight, GI SE transient, take with largest meals of the day
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metformin CI
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renal insufficiency (SCr>1.4(F) or 1.5 (M)), hepatic dysfunction, risk of lactic acidosis
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DM meds that can cause weight gain (3 classes)
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sulfonylureas, TZDs, insulin,
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TZD MOA
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improves insulin sensitivity
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metformin CIs
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renal dysfx (SCr >1.4 (F) or 1.5 (M)), hepatic dyfx, excessive alcohol use. Watch for lactic acidosis.
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Sucrose won't be effective for hypoglycemia if on these meds
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alpha-glucosidase inhibitors (acarbose, miglitol). Use lactose or fructose.
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Rapid acting insulins (3)
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glulisine (Apidra), aspart (Novolog), lispro (Humalog)
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intermediate acting insulins (10-24 h) (2)
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NPH (Novolin N, Humulin N), Lente
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long-acting insulins (18-30 h)
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Ultralente
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Basal insulins (18-24 h) (2)
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glargine (Lantus), detemir (Levemir
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When mixing insulins, which should be drawn up first?
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Regular. Slow-acting insulins should be last.
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thyroid hormones: T3 vs T4
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T4 is originally secreted; turns into more potent T3 in tissues. Levothyroxine is T3.
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antithyroid meds (4)
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PTU, methimazole, Lugol's solution, SSKI
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Cushings dz treatment (4)
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Supress cortisol synthesis with: ketoconazole(Nizoral), aminoglutethimide, metyrapone, mitotane
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Used to diagnose adrenal insufficiency
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Cosynotropin (Cortrosyn), corticotropin (Acthar, ACTH)
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vitamin D's effects in CKD
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increased absorption and reabsorption of Ca, suppressed PTH, increased phosphorus absorption. May need to be d/c'ed in hypercalcemia/ hyperphosphatemia
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Cinacalcet (Sensipar) MOA
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Calcimimetic: binds to calcium receptors on parathyroid, thereby decrease stimulus for PTH release
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