Naloxone D021 (V.22/07020)

Front 1

Naloxone Presentation

Back 1

0.4 mg in 1ml

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Naloxone Pharmacology & Action

Back 2

A Opioid Antagonist

Action:

Prevents or reverses the effects of opioids

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Naloxone Metabolism

Back 3

By the liver

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Naloxone Primary Emergency Indications

Back 4

Altered conscious state and

respiratory depression secondary

to administration of narcotics or related drugs

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Naloxone Contraindications

Back 5

Nil of significance in above indication

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Naloxone Precautions

Back 6

1. If patient is known to be physically dependent
on narcotics, be prepared to deal with a
combative pt after administration

2. Neonates

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Naloxone Route of Administration

Back 7

Intramuscular

Intravenous

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Naloxone Side Effects

Back 8

1. Symptoms of narcotic withdrawal
Sweating, goose flesh, tremor

3. Nausea and vomiting

4. Agitation

5. Dilation of pupils, excessive lacrimation

6. Convulsions

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Naloxone Special Notes

Duration / Effects

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Since the duration of action of Naloxone is often less than that of the opioid used, therefore

repeated doses may be required.

Naloxone reverses the effects of opioids with none of the actions produced by other opioid

antagonists when no narcotic is present on the body. ( E.g no respiratory depression or pupillary constriction) In the absence of opioids, Naloxone has no perceivable effects.

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Naloxone Special Notes

Cardiac Arrest / Head Injury

Back 10

Following an opioid associated cardiac arrest Naloxone should not be administered.

Maintain assisted ventilation.

Following head injury Naloxone should not be administered.

Maintain assisted ventilation if required.

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Naloxone Times

Back 11

IV / IM effects:

Onset: 1 - 3 min

Peak: n/a

Duration 30 - 45 min