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47 Cards in this Set
- Front
- Back
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Catecholamine
Members |
Epinephrine
Norepinephrine Isoproterenol Dopamine Dobutamine |
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Catecholamine
Properties |
Cannot be used orally
Brief duration of action Cannot cross BBB |
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Noncatecholamines
Members |
Ephedrine
Phenylephrine Terbutaline |
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Noncatecholamines
Properties |
Can be used orally
Longer duration of action Can cross BBB |
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A1 Activation
Agonists |
Epinephrine
Norepinephrine Phentlephrine Ephedrine Dopamine |
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A1 Activation
Therapeutic Effects |
• Hemostasis: topical epinephrine
• Nasal decongestion: oral ephedrine • Local anesthesia: epinephrine • Hypotension: epinephrine, NE, Dopamine • Mydriasis: eye exams |
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A1 Activation
Adverse Effects |
• HTN: excessive vasoconstriction
• Necrosis: extravasation • Bradycardia: baroreceptor reflex to HTN |
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A2 Activation
Agonists |
Epinephrine
Norepinephrine Ephedrine |
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A2 Activation
Therapeutic Effects |
None in periphery
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A2 Activation
Adverse Effects |
None in periphery
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B1 Activation
Agonists |
Epinephrine
Norepinephrine Isoproterenol Dopamine Dobutamine Ephedrine |
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B1 Activation
Therapeutic Effects |
•Cardiac arrest
•Heart failure •Shock •AV block |
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B1 Activation
Adverse Effects |
• Tachycardia
• Arrhythmia • Angina |
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B2 Activation
Agonists |
Epinephrine
Isoproterenol Ephedrine Terbutaline |
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B2 Activation
Therapeutic Effects |
• Asthma
• Delay of preterm labor |
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B2 Activation
Adverse Effects |
• Hyperglycemia
• Tremor |
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Dopamine Activation
Agonists |
Dopamine
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Dopamine Activation
Therapeutic Effects |
Prevention of Renal Failure
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Epinephrine
trade Type |
Adrenalin©
Catecholamines |
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Epinephrine
USED |
Cardiac Arrest, anaphylaxix,
Hypotension Hemostasis, local anesthesia Mydriasis AV Block Asthma Croup BB/CCB OD |
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Epinephrine
Dose |
Cardiac Arrest: 1mg 1:10,000 RIVP q 3-5 mins
Anaphylaxis: 0.3mg 1:1000 IM q 5 m (max 0.9mg) then 0.1mg 1:10000 IVP q 2min (max 1mg) Asthma: 0.3mg 1:1000 IM q 20 min (max 0.9mg) Croup: 5mg 1:1000 Nebulized, may repeat once BB/CCB OD: 2-10mcg/min drip, Titrate to BP Hypotension: Same as above |
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Epinephrine
ADVERSE EFFECTS |
- HTN crisis
- angina -necrosis -arrhythmia -hyperglycemia |
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Epinephrine
Drug Interactions |
-MAOI-prolong / intensity effects
-TCA’s- catecholamine reuptake blockade -inhalation anesthetics; cardiac hypersensitivity -alpha & beta blockers |
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Epinephrine
Pharmacokinetics |
-no oral admin due: MAO & COMT
-half life due to same -no cross BBB due: polar molecule |
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Epinephrine
Receptors |
Dopamine, β1, α1
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Norepinephrine
Trade type |
Levophed©
Catecholamines |
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Norepinephrine
USED FOR |
-hypotension
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Norepinephrine
Dose: |
0.5-30mcg/min Drip, Titrate to BP
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Norepinephrine
Receptors |
A1, A2, B1
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Isoproterenol
Trade type |
Isuprel©
Catecholamines |
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Isoproterenol
USED |
-AV Block
-Cardiac Arrest -Shock -Asthma |
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Isoproterenol
Dose |
Unstable Bradycardia: 2-10mcg/min Drip, Titrate to effect
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Isoproterenol
Receptors |
B1, B2
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Isoproterenol
ADVERSE |
hyperglycemia
angina tachycardia arrhythmia |
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Isoproterenol
CAUTION |
Ischemic heart disease
Tachydysrhythmias May precip VF/VT |
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Isoproterenol
INTERACTIONS |
TCA
MAOI’s Inhalation Anesthetics Beta Blockers |
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Dopamine
trade type |
Intropin©
Catecholamines |
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Dopamine
USED |
Bradycardia,
Hypotension Heart failure |
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Dopamine
MOA |
-dose dependent
-low - dopamine -moderate -Ba -High- A1 |
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Dopamine
DOSE |
Renal: 2-5mcg/kg/min
B1: 5-10mcg/kg/min A1: 10-20mcg/kg/min Overall: 2-20mcg/kg/min Drip, titrate to effect |
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Dopamine
Receptors |
Dopamine
β1 α1 |
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Dopamine
ADVERSE |
- tachycardia
- angina -arrhythmia -necrosis |
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Dopamine
INTERACTIONS |
- MAOI, TCA
-inhalation anesthetics |
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Dobutamine
Trade type |
Dobutrex©
Catecholamines |
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Dobutamine
USED |
Heart failure
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Dobutamine
Dose |
2-20mcg/kg/min Drip, titrate to effect
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Dobutamine
Receptors |
B1
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