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31 Cards in this Set
- Front
- Back
Lung Functions |
-Alveolar ventilation
-Gas diffusion -Lung perfusion |
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Structures- Lungs
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-Divided into left and right
-Left has two lobes -Right has three lobes -Between the lungs is the mediastinum that contains the heart, esophagus, and great vessels. -Mucous in lungs traps bacteria and expels it by coughing. |
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Structures - Airways
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-Upper airway includes the nose, nasalpharynx, oropharynx, and larynx.
-Nose warms, humidifies, and filters inspired air. By the time air reaches the alveoli it is 100% saturated with moisture. -250 ml per day insensible water loss -Larynx connects the upper and lower airway. -Epiglottis closes off the larynx during swallowing. |
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Lower airway
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-Trachea, bronchi, carina, bronchioles, and alveoli.
-Trachea divides into two mainstem bronchi at the level of the carina. -Carina is sensitive and when stimulated will produce coughing. -Right mainstem bronchus extends from the trachea more vertically than the left therefore there is a greater tendency to aspirate into the right lung. -Right mainstem bronchus terminates into bronchioloes which terminate into alveoli. |
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Structures - Gas Exchange
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-Bronchioles and alveoli are units of gas exchange.
-300 million alveoli that have a potential volume of 2500 ml. -Everything above the terminal bronchioles and alveoli is anatomical dead space. -Tidal volume is 500 ml, dead space 150 ml. |
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Structure - Alveoli
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-Primary unit of gas exchange
-Contain two types of epithelial cells -Type I provides structure -Type II secrete surfactant -Alveoli contain macrophages to ingest foreign material and remove it through the lymph system. |
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Surfactant
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-A lipoprotein that coats the inside of the alveoli.
-Promotes expansion of alveoli during inspiration. -Decreases the work of ---Breathing and ---Surface tension |
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Pulmonary Circulation
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-Pulmonary artery divides into arterioles that follow the path of each bronchus and bronchiole.
-The capillary wall and alveolar wall are one cell thick, promoting gas exchange. -If damaged can become permeable to plasma and blood entering the alveolar space. |
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Chest wall and pleura |
-Chest wall consists of skin, ribs, and intercostal muscles that perform the work of breathing along with the diaphram.
-Pleural lining attached to the lungs is the visceral lining. This lining folds on itself and attaches to the chest wall as the parietal pleura. -Pleural space – a potential space between the two linings that contains a thin layer of pleural fluid. |
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Ventilation
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-The mechanical movement of gas into and out of the lungs.
-Breathing is usually involuntary with rate and depth of respiration controlled by the autonomic nervous system in response to changes in blood gas and pH levels. -Can be voluntary during talking, eating, or holding our breath. |
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Mechanics of inhalation
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-Diaphragm contracts and volume of the thoracic cavity increases.
-Negative pressure causes air to enter the lungs. -Contraction of the external intercostals elevates the rib cage expanding the chest even more. -Accessory muscles like the sternocleidomastoid and scalene also increase the volume of the chest. -Expiration is passive. -Most people sigh every 5-6 breaths. This causes surfactant to be secreted. |
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Elastic recoil
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-Property of lungs which along with surface tension of water causes lungs to withdraw or collapse if they loose their relationship with the chest wall.
-It is the integrity of the pleural space that keeps lungs expanded. |
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Compliance
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-A measure of the lung and chest wall distensibility.
-A decrease in compliance indicates a lung that is difficult to inflate. |
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Gas Exchange
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-PaO2 is amount of oxygen dissolved in plasma.
-PAO2 is the amount of alveolar oxygen. -SaO2 is the amount of oxygen bound to hemoglobin in comparison to the amount of oxygen hemoglobin can carry. -Example 90% SaO2 means that 90% of hemoglobin's attachments for oxygen are bound with oxygen. |
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Ventilation Perfusion Ratio
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-Segments of the lung ventilate and perfuse with differing efficiency.
-Apex of the lung ventilation exceeds perfusion. -Base of the lung perfusion exceeds ventilation. -Averages out to a V/Q ratio of 0.8 -Low ventilation to perfusion mucous plug -High ventilation to perfusion PE |
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Oxyhemoglobin Curve (shift to the left)
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-Shift to the left
-Hemoglobin has a greater attraction to oxygen. -Alkalosis -Hypocapnea -Hypothermia |
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Oxyhemoglobin Curve (shift to the right)
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-Shift to the right
-Hemoglobin has a decreased attraction for oxygen -Acidosis -Hypercapnea -Hyperthermia |
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Why is it so important to keep O2 Sats above 90%?
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-See GRAPH on lecture notes
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Why are we doing pulse oximetry?
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-Blood gases are expensive to perform too often
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Bohr Effect (shift to the right)
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- decreased pH
- increased Temperature - increased PCO2 - increased 2,3-DPG |
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2,3 DPG
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-found in red blood cells
-if low, then shift to the LEFT |
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What is the Tidal Volume in a lung?
Dead space? |
500 ml
150 ml |
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What type of epithelial cells produce surfactant?
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Type II
Type I provide structure |
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How does Surfactant work?
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promotes expansion of the alveoli during inspiration
decreases work of breathing and surface tension |
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It is the integrity of what that keeps lungs expanded?
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pleural space
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What is compliance?
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measure of lung and chest wall distensibility
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What is the avg V/Q ratio?
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0.8
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Hemoglobin has an attraction to what if there is a Oxyhemoglobin curve to the left?
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oxygen
causes alkolosis hypocapnea hypothermia |
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Hemoglobin has a decreased attraction to what if there is a Oxyhemoglobin curve to the left?
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oxygen causes
acidosis hypercapnea hyperthermia |
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What is the name of a shift to the right on the Oxyhemoglobin scale>
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Bohr effect
decreased pH increased: PCO2, temp, 2,3-DPG |
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What in the world is 3-DPG?
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found in red bl. cells
if low then curve shifts to left |