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20 Cards in this Set
- Front
- Back
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What class of myopathy tend to be early onset (childhood) and progressive?
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Muscular dystrophy
Duchenne is MC |
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What class of myopathy tend to be neonatal onset and slow or non-progressing?
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Congenital
Must be characterized by muscle biopsy |
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What class of myopathy tend to have cramps and myoglobinuria with exercise but not rest, and have associated CNS disorders?
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Metabolic or mitochondrial
Tend to have glycogen or lipid metabolism dysfunction too |
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What class of myopathy have high CK levels, happen rapidly, and are associated with GU neoplasms?
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Inflamatory
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What drugs cna cause myopathy?
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Colchicine
AZT chloroquine/hydoxycholorquine steroids statins |
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Most common cause of endocrine myopathy?
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Hyper/hypothyroid
Hyperparathyroid |
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What is myotonic syndrome?
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Inherited alterations in muscle ion channels
Teen/adult presentation inital issue with releasing objects Progresses to distal m weakness |
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What muscles are commonly affected in myopathies?
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Proximal LE and hip
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What Dx studies are important if you suspect a myopathy?
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Serum CK (with cardiac enzymes)
NCS/EMG Biopsy MRI |
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What is the dx if a pt presents with double vision, variable weakness, that worsens with exertion?
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Myasthenia Gravis
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If you have a pt with myasthenia gravis, what dx test must the have?
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Chest CT looking for thymomas
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What condition does a pt have if they have a positive edrophonium (tensilon) test?
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Myasthenia gravis
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Myasthenic crisis or cholinergic crisis?
Resp distress, increased pulse and bp, dysphagia |
Myasthenic crisis
treat with tensilon |
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Myasthenic crisis or cholinergic crisis?
Abdominal cramping, d/n/v, tears running down their face |
Cholinergic crisis
can get with pyridostigmine |
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Dx if a pt presents with variable weakness, trouble walking, and their weakness improves with exercise?
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Lambert Eaton Myasthenic syndrome
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What does a pt with LEMS need to be screened for?
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Small cell carcinoma of the lung
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What is the most common inflamatory myopathy in children?
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Dermatomyositis
rash on face/boney prominances |
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What CA is dermatomyositis associated with?
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Breast, lung, bowel, female genital
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What are the sx of Polymyositis?
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Proximal muscles more affected
rare before 18, more women |
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What are the sx of Inclusion body myositis?
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Proximal and distal muscle weakness and atrophy
Men more than women, usually >50 |
