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7 Cards in this Set
- Front
- Back
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What are the typical lab findings in Chronic Myelogenous Leukemia?
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Thrombocytosis
<10% blasts in PB >100,000 WBC/L Very high M:E (10:1-50:1) |
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Thrombocytopenia, NRBC, >20% basophils and an increase in promyelocytes is consistant with what phase of CML?
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The accelerated phase
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The translocation of ABL-1(q34) and BCR(q11) results in the formation of this abnormal chromosome found in 90% of patients diagnosed with CML
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Philadelphia or Ph chromosome.
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An LAP score >100 can indicate what conditions?
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Leukmoid reaction, Polycythemia Vera
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State the expected lab findings for CIMF
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tear drop cells, large platelets BM fibrosis, initial increase in WBC and platelets but decreases as disease progresses
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Identify the chromosomal abnormality associated with CML and explain how this finding correlates with prognosis.
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Ph chromosome(fusion of ABL-1 and BCR)
The protien produced by this chromosome (p210BCR-ABL) does not allow for abnormal cell destrucion leading to an increase in the WBC. |
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Compare and contrast the usual platelet and red cell counts in AML vs. CML.
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In AML both are decreased in CML both are increased.
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