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22 Cards in this Set
- Front
- Back
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What is the mutation associated with chronic myelogenous leukemia? What is the result?
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9:22 translocation
bcr/abl fusion protein- proliferation of hematopoietic cells, especially myeloid. |
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What is the presentation of chronic myelogenous leukemia?
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Fevers, bone pain, fatigue.
Splenomegaly |
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What are lab findings in chronic myelogenous leukemia?
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Increased white cells, especially immature cells
Marrow with increased cellularity 9:22 translocation on PCR or FISH |
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What is the prognosis of chronic myelogenous leukemia?
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Converts to acute leukemia in 5 years.
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What are the treatment options for chronic myelogenous leukemia?
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Hydroxyurea
Interferon Marrow transplant Imatinib |
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What is Imatinib?
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Binds specifically to bcr/abl protein and inactivates it.
Chronic myelogenous leukemia. |
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What is polycythemia vera?
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Red cells proliferate unregulated.
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How does a patient present with polycythemia vera?
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Splenomegaly
Headache Blurred vision Itching after shower |
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What are lab findings with polycythemia vera?
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Erythropoietin levels are low
Marrow hypercellularity JAK2 mutation on PCR |
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What is the treatment for polycythemia vera?
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Phlebotomy
Hydroxyurea |
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What is the prognosis for polycythemia vera?
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7-12 year survival
Can progress to myelofibrosis |
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What is essential thrombocytosis?
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Proliferation of megakaryocytes and increased platelet counts.
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How does a patient present with essential thrombocytosis?
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Usually asymptomatic
Increased risk for thrombosis |
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What are lab findings in essential thrombocytosis?
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Splenemegaly
Marrow has increased megakaryocytes JAK2 mutation Need to distinguish reactive thrombocytosis. |
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What is the treatment for essential thrombocytosis?
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Aspirin
Hydroxyurea Anagrelide |
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What is anagrelide?
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Controls platelet counts in essential thrombocytosis?
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What is the prognosis for essential thrombocytosis?
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Usually more than 10 years
Low risk of acute leukemia |
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What is agnogenic myeloid metaplasia?
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Proliferation of fibroblasts seen in bone marrow and extramedullary hematopoiesis.
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How does a patient present with agnogenic myeloid metaplasia?
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Fatigue
Abdominal pain Splenomegaly |
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What are lab results in agnogenic myeloid metaplasia?
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Teardrop red cells
Immature white cells Dry tap on marrow aspirate JAK2 mutation |
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What is the prognosis for agnogenic myeloid metaplasia?
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5-7 year survival
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What is ruxolitinib?
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JAK2 inhibitor to shrink spleen with myeloproliferative disorders.
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