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42 Cards in this Set
- Front
- Back
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IV. Poorly absorbed through skin.
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AMPHOTERICIN
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High efficiency. Not many doses.
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AMPHOTERICIN
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Binds to ergosterol enzymes,
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AMPHOTERICIN
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Creating leaky cells.
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AMPHOTERICIN
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Many nasty side effects: Fever, vomiting, convulsions, nephrotoxicity.
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AMPHOTERICIN
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Can hide drug in lipid globule to reduce.
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AMPHOTERICIN
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Isolated from streptomyces. A bacteria.
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AMPHOTERICIN
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Orally. Well absorbed in GI.
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FLUCYTOSIN
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Resistance builds quickly.
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FLUCYTOSIN
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Usually given along with ampho-B.
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FLUCYTOSIN
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Disrupts fungal protein synthesis, distorting RNA structure.
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FLUCYTOSIN
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Many nasty side effects: Leukpenia, thrombocytopenia, hepatotoxicity and nephrotoxicity.
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FLUCYTOSIN
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Aspergillus is resistant.
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FLUCYTOSIN
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Gut and skin absorption. (orally/topically?)
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KETOCONAZOLE
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Disrupts ergosterol in fungal membranes (but can hurt ours too)
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KETOCONAZOLE
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Many nasty side effects: vomiting, liver problems, rash, toxigenicity.
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KETOCONAZOLE
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Useful for dermatophytes (athlete’s foot and toenail fungi)
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KETOCONAZOLE
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Orally.
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ITRACONAZOLE
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Ergosterol.
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ITRACONAZOLE
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Relatively minor side effects.
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ITRACONAZOLE
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GI problems, rash, hypokalemia.
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ITRACONAZOLE
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Good for systemic mycoses and superficial infections.
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ITRACONAZOLE
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No known resistances!
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ITRACONAZOLE
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Oral & IV.
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FLUCONAZOLE
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Relatively minor side effects.
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FLUCONAZOLE
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Drug reaches CNS.
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FLUCONAZOLE
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Used in AIDS patients along with ampho-B.
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FLUCONAZOLE
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Orally & Topically.
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CLOTRIMAZOLE
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Treatment for yeast infections.
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CLOTRIMAZOLE
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Only used if patient doesn’t respond to other treatments.
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MICONAZOLE
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Glucan synthesis inhibitor. (component of fungal cell walls)
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ECHINOCANDINS
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Mild. Humans don’t have glucan.
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ECHINOCANDINS
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Good against aspergillus and candida.
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ECHINOCANDINS
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Important for hospitals.
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ECHINOCANDINS
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Orally. Peaks quickly in blood.
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GRISEOFULVIN
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Very toxigenic! Severe side effects.
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GRISEOFULVIN
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Not used anymore.
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GRISEOFULVIN
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Used for ringworm and athlete’s foot.
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GRISEOFULVIN
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Ergosterol.
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TERBINAFINE
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Best used on nails due to minimal side effects.
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TERBINAFINE
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Treats fungal infections of skin, nails, hair.
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TERBINAFINE
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Only over the counter drug listed here.
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TERBINAFINE
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