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15 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Why are antifungal agents toxic for us?
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Because we are both eukaryotes.
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T/F Treatment for fungal infections is very short.
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Nope. Very long - weeks and months.
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How do polyenes work?
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They act by binding to the fungal cell membrane and causing the fungus to leak electrolytes, namely potassium. This causes water to enter the cell and the cell lyses.
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Two main polyene examples:
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Amphotericin B
Nystatin |
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T/F Polyenes are very potent
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True.
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How do we administer polyenes?
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IV
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Polyenes are toxic to the____.
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kidneys
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What is a liposome?
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New technique. It's a tiny bubble, made out of phospholipids that can be filled with drugs, and used for administration.
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How do Azoles work?
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Inhibit the synthesis of ergosterol by blocking the action of 14-alpha-demethylase. Don't affect any existing membranes.
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Is the group of Azoles large or small? Why?
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A very large group, as they don't work on all the fungi. Different structures are needed for different fungi.
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Allylamines: Terbinafine
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Inhibits squalene epoxidase. This enzyme blocks the synthesis of ergosterol, although by blocking a different enzyme than is blocked by the Azoles.
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Flucytosine is the only available __(a)__ drug having __(b)__activity. It inhibits fungal protein synthesis by replacing __(c)__ with 5-flurouracil in fungal __(d)__. Flucytosine also interferes with fungal __(e)__ synthesis .
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a. antimetabolite
b. antifungal c. uracil d. RNA e. DNA |
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There are three main glucan synthesis inhibitors, all belonging to the echinocandins.
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Caspofungin
Micafungin V-echinocandin |
C M V-e
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Griseofulvin inhibits fungal __(a)__by disrupting the __(b)__ through interaction with polymerized __(c)__.
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a. mitosis
b. mitotic spindle c. microtubules |
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Sordarins are:
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A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts.
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