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22 Cards in this Set
- Front
- Back
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borderline tumors
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features in between benign and malignant
-better prognosis (but still malignant) |
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BRCA1 mutation
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inc. risk of breast and OVARY cancer (and fallopian tube)
-most commonly serous carcinoma |
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surface tumors present late, leading to?
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poor prognosis
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3 mechanisms of spread?
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sarcomas - spread via vasculature
carcinomas - spread via lymphatics ovarian (epithelial carcinomas) spread into peritoneum |
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Mucinous tumors
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-Less common than serous tumors
-Multi-locular cysts, gelationous, mucous filled -Lining cells are goblet-cell like |
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what does serous mean (for a tumor?)
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… thin and watery fluid.. These tumors are often cystic with clear serous fluid.
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serous tumor
-morphology? |
One large cysts;
clear serous fluid-filled Cyst lining is ciliated columnar cells, single layer of serous cells |
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serous tumor
-Clinical features? |
30% of ovarian tumors
75% are benign - Most common malignant ovarian tumor - Often bilateral -premenopausal women (30-40) |
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Serous Borderline Tumors
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Implants
-30% of cases may have implants, i.e. tumor in pelvic peritoneum, omentum To emphasize their good prognosis, extraovarian disease is not termed “metastases” but “implants” |
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why termed implants?
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30% of cases may have implants, i.e. tumor in pelvic peritoneum, omentum
To emphasize their good prognosis, extraovarian disease is not termed “metastases” but “implants” |
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borderline tumors
|
features in between benign and malignant
-better prognosis (but still malignant) |
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BRCA1 mutation
|
inc. risk of breast and OVARY cancer (and fallopian tube)
-most commonly serous carcinoma |
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surface tumors present late, leading to?
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poor prognosis
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3 mechanisms of spread?
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sarcomas - spread via vasculature
carcinomas - spread via lymphatics ovarian (epithelial carcinomas) spread into peritoneum |
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Mucinous tumors
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-Less common than serous tumors
-Multi-locular cysts, gelationous, mucous filled -Lining cells are goblet-cell like |
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Germ cell tumors of the ovary
Origin |
Most are benign teratomas (46 XX) (dermoid cysts/ mature teratomas)
-Meiotic germ cell |
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5 types of germ cell tumors?
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Fetal cells:
1) cystic teratoma 2) embryonal carcinoma Yolk sac cells: 3) Yolk sac carcinoma Germ cell: 4) Dysgerminoma Placental cells: 5) Choriocarcinoma |
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Teratoma types?
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Mature and malignant
-Mature- Most common, frequently bilateral (10-15%) Mature elements from one or more germ layers Malignant- |
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Teratoma
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any type of tissue can be found, hair, bone, tooth, skin
-Benign (most common benign ovarian tumor in female) |
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somatic malignancy of teratoma?
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cancer of cells of the mature cells within a teratoma (within the skin of teratome, cancer developts_
-most common is squamous cell carcinoma |
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dysgerminoma, cell appearance?
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-large cells with clear cytoplasm and central nuclei (resemble oocytes)
-most common malignant germ cell tumor |
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most common benign germ cell tumor?
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teratoma
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