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64 Cards in this Set

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Another name for Buerger's disease?
thromboangiitis obliterans
describe Buerger's disease
segmental, thrombosing vasculitis of intermediate and small peripheral arteries and veins
demographics of Buerger's disease
seen in heavy smokers
findings in Buerger's disease
Intermittent claudication
superficial nodular phlebitis
cold sensitivity (Raynaud's phenomenon)
severe pain in affected part; may lead to gangrene
tx for Buerger's disease
quit smoking
Takayasu's arteritis is also known as
the "pulseless disease"
describe Takayasu's arteritis
granulomatous thickening of aortic arch and/or proximal great vessels. Associated with an elevated ESR
demographics of Takayasu's arteritis
Asian females <40 y.o.
symptoms of Takayasu's arteritis
Fever
Arthritis
Night sweats
MYalgia
SKIN nodules
Ocular disturbances
Weak pulses in upper extremities

"FAN MY SKIN On Wednesday"
"FAN MY SKIN On Wednesday"
Temporal arteritis is also known as
giant cell arteritis
Temporal arteritis (giant cell arteritis) affects which arteries?
medium and small arteries, usually branches of the carotid artery.
which arteritis affects medium and small arteries, usually branches of the carotid artery?
Temporal (giant cell) arteritis
which arteritis affects medium arnd larger arteries - aortic arch and/or proximal great vessels?
Takayasu's arteritis
which arteritis affects intermediate and small peripheral arteries and veins?
Buerger's disease
Findings in temporal (giant cell) arteritis
unilateral headache, jaw claudication, impaired vision (occlusion of the ophthalmic artery, which can lead to blindness).
temporal arteritis is associated with what other disease?
half of patients have systemic involvement and polymyalgia rheumatica (proximal muscle pain, periarticular pain)
Is ESR elevated in temporal (giant cell) arteritis
ESR is markedly elevated
tx for temporal (giant cell) arteritis
steroids
demographics of temporal (giant cell) arteritis
elderly females
is temporal (Giant cell) arteritis granulomatous?
yes, it's focal, granulomatous
Polyarteritis Nodosa is characterized by
necrotizing immune complex inflammation of medium-sized muscular arteries, typically involving renal and visceral vessels
"necrotizing immune complex inflammation of medium-sized muscular arteries, typically involving renal and visceral vessels" - discribes which diesease?
Polyarteritis Nodosa
10 Systemic symptomes of PAN
fever
weigh loss
malaise
abdominal pain
melena
headache
mylagia
hypertension
neurologic dysfunction
cutaneous eruptions
f
w
m
a
m
h
m
h
n
c
PAN is associated with which other disease?
Hep B seropositivity in 30% of patients
Findings on arteriogram in PAN
multiple aneurysms and constrictions on arteriogram
tx for PAN
corticosteroids, cyclophosphamide
Wegener's granulomatosis is characterized by
triad of
focal necrotizing vasculitis,
necrotizing granulomas in the lung and upper airway,
necrotizing glomerulonephritis
symptoms of wegener's granulomatous
perforation of nasal septum
chronic sinusitis
otits media
mastoiditis
cough
dyspnea
hemoptysis
hematuria
saddle-nose
Findings in wegener's granulomatous
C-ANCA is a strong marker
chest x-ray may reveal large nodular densities
hematuria and red cell casts
tx. for wegener's granulomatous
cyclophosphamide and corticosteroids
ANCA positive vasculitides
Wegener's granulomatous
Microscopic polyangiitis - P or C-ANCA
primary pauci-immune crescentic glomerulonephritis
Churg-Strauss syndrome

PAN can be associated with P-ANCA
describe Microscopic polyangiitis
like wegener's but lacks granulomas

P- or C-ANCA
primary pauci-immune crescentic glomerulonephritis
vasculitis limited to kidney
describe Churg-Strauss syndrome
granulomatous vasculitis with eosinophilia. Involves heart, lung, skin, kidneys, nerves.

Often seen in atopic pts. ass. w/ asthma
describe Kawasaki disease (demographic, vessel size, symptoms complications)
acute, self-limiting disease of infants/kids.
acute necrotizing vasculitis of small/medium sized vessels

Fever, congested conjunctiva, changes in lips/oral mucosa, lymphadenitis.

May develope coronary aneurysms
describe Henoch-Schonlein purpura
Most common form of childhood systemic vasculitis.

skin rash, arthralgia, intestinal hemorrhage, abdominal pain, and melena
2 large vessel vasculitis
Takayasu's
giant cell
3 Medium vessel vasculitis
PAN
Kawasaki's
Isolated CNS vasculitis
3 small vessel vasculitis
wegener's granulomatosis
churg strauss granulomatosis
microscopic polyangiitis

-these are all ANCA positive
Also known as thromboangiitis obliterans;
Buerger’s disease
idiopathic, segmental, thrombosing vasculitis
of intermediate and small peripheral arteries and veins.
Buerger’s disease
Intermittent claudication, superficial nodular phlebitis, cold sensitivity
(Raynaud’s phenomenon), severe pain in affected part; may lead to gangrene.
Buerger’s disease
Known as “pulseless disease”
Takayasu’s arteritis
Weak pulses in upper extremities.
Takayasu’s arteritis
granulomatous thickening of aortic arch and/or proximal great arteries.
Takayasu’s arteritis
Associated with elevated ESR.
Takayasu’s arteritis

Temporal arteritis (giant cell arteritis)
Half of patients have systemic
involvement and polymyalgia rheumatica
(proximal muscle pain, periarticular pain).
Temporal arteritis (giant cell arteritis)
Most common vasculitis that affects medium and small arteries, usually branches of carotid artery.
Temporal arteritis (giant cell arteritis
Focal, granulomatous. Findings include unilateral headache, jaw claudication, impaired vision (occlusion of ophthalmic artery, which can lead to blindness).
Temporal arteritis (giant cell arteritis
Lesions are of different ages.
Polyarteritis Nodosa
Fever, weight loss, malaise, abdominal pain, melena, headache, myalgia, hypertension, neurologic
dysfunction, cutaneous eruptions.
Polyarteritis Nodosa
Hepatitis B seropositivity in 30% of patients. Multiple
aneurysms and constrictions on arteriogram.
Polyarteritis Nodosa
Characterized by necrotizing immune complex inflammation of medium-sized muscular arteries, typically involving renal and visceral vessels.
Polyarteritis Nodosa
Characterized by triad of focal necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, and necrotizing glomerulonephritis.
Wegener's Granulomatosis
Perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis, cough, dyspnea, hemoptysis, hematuria.
Wegener’s granulomatosis
C-ANCA is a strong marker of disease; chest x-ray may reveal large nodular densities; hematuria and red cell casts.
Wegener’s granulomatosis
Like Wegener’s but lacks granulomas. P- or C-ANCA.
Microscopic polyangiitis
Vasculitis limited to kidney.
1° pauci-immune crescentic glomerulonephritis
Granulomatous vasculitis with eosinophilia. Involves lung, heart, skin, kidneys, nerves.
Churg-Strauss Syndrome
Often seen in atopic patients.
Churg-Strauss Syndrome
Acute, self-limiting disease of infants/kids.
Kawasaki disease
Acute, self-limiting disease of infants/kids. Acute necrotizing vasculitis of small/
medium-sized vessels. Fever, congested conjunctiva, changes in lips/oral mucosa,
lymphadenitis. May develop coronary aneurysms.
Acute necrotizing vasculitis of small/medium-sized vessels. Fever, congested conjunctiva, changes in lips/oral mucosa, lymphadenitis. May develop coronary aneurysms.
Kawasaki disease
Acute, self-limiting disease of infants/kids. Acute necrotizing vasculitis of small/
medium-sized vessels. Fever, congested conjunctiva, changes in lips/oral mucosa,
lymphadenitis. May develop coronary aneurysms.
Most common form of childhood systemic vasculitis.
Henoch-Schönlein purpura
Skin rash, arthralgia, intestinal hemorrhage, abdominal pain, and melena.
Henoch-Schönlein purpura