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64 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Another name for Buerger's disease?
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thromboangiitis obliterans
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describe Buerger's disease
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segmental, thrombosing vasculitis of intermediate and small peripheral arteries and veins
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demographics of Buerger's disease
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seen in heavy smokers
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findings in Buerger's disease
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Intermittent claudication
superficial nodular phlebitis cold sensitivity (Raynaud's phenomenon) severe pain in affected part; may lead to gangrene |
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tx for Buerger's disease
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quit smoking
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Takayasu's arteritis is also known as
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the "pulseless disease"
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describe Takayasu's arteritis
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granulomatous thickening of aortic arch and/or proximal great vessels. Associated with an elevated ESR
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demographics of Takayasu's arteritis
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Asian females <40 y.o.
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symptoms of Takayasu's arteritis
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Fever
Arthritis Night sweats MYalgia SKIN nodules Ocular disturbances Weak pulses in upper extremities "FAN MY SKIN On Wednesday" |
"FAN MY SKIN On Wednesday"
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Temporal arteritis is also known as
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giant cell arteritis
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Temporal arteritis (giant cell arteritis) affects which arteries?
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medium and small arteries, usually branches of the carotid artery.
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which arteritis affects medium and small arteries, usually branches of the carotid artery?
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Temporal (giant cell) arteritis
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which arteritis affects medium arnd larger arteries - aortic arch and/or proximal great vessels?
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Takayasu's arteritis
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which arteritis affects intermediate and small peripheral arteries and veins?
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Buerger's disease
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Findings in temporal (giant cell) arteritis
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unilateral headache, jaw claudication, impaired vision (occlusion of the ophthalmic artery, which can lead to blindness).
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temporal arteritis is associated with what other disease?
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half of patients have systemic involvement and polymyalgia rheumatica (proximal muscle pain, periarticular pain)
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Is ESR elevated in temporal (giant cell) arteritis
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ESR is markedly elevated
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tx for temporal (giant cell) arteritis
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steroids
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demographics of temporal (giant cell) arteritis
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elderly females
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is temporal (Giant cell) arteritis granulomatous?
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yes, it's focal, granulomatous
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Polyarteritis Nodosa is characterized by
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necrotizing immune complex inflammation of medium-sized muscular arteries, typically involving renal and visceral vessels
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"necrotizing immune complex inflammation of medium-sized muscular arteries, typically involving renal and visceral vessels" - discribes which diesease?
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Polyarteritis Nodosa
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10 Systemic symptomes of PAN
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fever
weigh loss malaise abdominal pain melena headache mylagia hypertension neurologic dysfunction cutaneous eruptions |
f
w m a m h m h n c |
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PAN is associated with which other disease?
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Hep B seropositivity in 30% of patients
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Findings on arteriogram in PAN
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multiple aneurysms and constrictions on arteriogram
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tx for PAN
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corticosteroids, cyclophosphamide
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Wegener's granulomatosis is characterized by
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triad of
focal necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, necrotizing glomerulonephritis |
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symptoms of wegener's granulomatous
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perforation of nasal septum
chronic sinusitis otits media mastoiditis cough dyspnea hemoptysis hematuria saddle-nose |
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Findings in wegener's granulomatous
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C-ANCA is a strong marker
chest x-ray may reveal large nodular densities hematuria and red cell casts |
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tx. for wegener's granulomatous
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cyclophosphamide and corticosteroids
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ANCA positive vasculitides
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Wegener's granulomatous
Microscopic polyangiitis - P or C-ANCA primary pauci-immune crescentic glomerulonephritis Churg-Strauss syndrome PAN can be associated with P-ANCA |
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describe Microscopic polyangiitis
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like wegener's but lacks granulomas
P- or C-ANCA |
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primary pauci-immune crescentic glomerulonephritis
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vasculitis limited to kidney
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describe Churg-Strauss syndrome
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granulomatous vasculitis with eosinophilia. Involves heart, lung, skin, kidneys, nerves.
Often seen in atopic pts. ass. w/ asthma |
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describe Kawasaki disease (demographic, vessel size, symptoms complications)
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acute, self-limiting disease of infants/kids.
acute necrotizing vasculitis of small/medium sized vessels Fever, congested conjunctiva, changes in lips/oral mucosa, lymphadenitis. May develope coronary aneurysms |
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describe Henoch-Schonlein purpura
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Most common form of childhood systemic vasculitis.
skin rash, arthralgia, intestinal hemorrhage, abdominal pain, and melena |
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2 large vessel vasculitis
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Takayasu's
giant cell |
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3 Medium vessel vasculitis
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PAN
Kawasaki's Isolated CNS vasculitis |
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3 small vessel vasculitis
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wegener's granulomatosis
churg strauss granulomatosis microscopic polyangiitis -these are all ANCA positive |
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Also known as thromboangiitis obliterans;
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Buerger’s disease
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idiopathic, segmental, thrombosing vasculitis
of intermediate and small peripheral arteries and veins. |
Buerger’s disease
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Intermittent claudication, superficial nodular phlebitis, cold sensitivity
(Raynaud’s phenomenon), severe pain in affected part; may lead to gangrene. |
Buerger’s disease
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Known as “pulseless disease”
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Takayasu’s arteritis
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Weak pulses in upper extremities.
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Takayasu’s arteritis
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granulomatous thickening of aortic arch and/or proximal great arteries.
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Takayasu’s arteritis
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Associated with elevated ESR.
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Takayasu’s arteritis
Temporal arteritis (giant cell arteritis) |
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Half of patients have systemic
involvement and polymyalgia rheumatica (proximal muscle pain, periarticular pain). |
Temporal arteritis (giant cell arteritis)
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Most common vasculitis that affects medium and small arteries, usually branches of carotid artery.
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Temporal arteritis (giant cell arteritis
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Focal, granulomatous. Findings include unilateral headache, jaw claudication, impaired vision (occlusion of ophthalmic artery, which can lead to blindness).
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Temporal arteritis (giant cell arteritis
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Lesions are of different ages.
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Polyarteritis Nodosa
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Fever, weight loss, malaise, abdominal pain, melena, headache, myalgia, hypertension, neurologic
dysfunction, cutaneous eruptions. |
Polyarteritis Nodosa
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Hepatitis B seropositivity in 30% of patients. Multiple
aneurysms and constrictions on arteriogram. |
Polyarteritis Nodosa
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Characterized by necrotizing immune complex inflammation of medium-sized muscular arteries, typically involving renal and visceral vessels.
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Polyarteritis Nodosa
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Characterized by triad of focal necrotizing vasculitis, necrotizing granulomas in the lung and upper airway, and necrotizing glomerulonephritis.
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Wegener's Granulomatosis
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Perforation of nasal septum, chronic sinusitis, otitis media, mastoiditis, cough, dyspnea, hemoptysis, hematuria.
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Wegener’s granulomatosis
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C-ANCA is a strong marker of disease; chest x-ray may reveal large nodular densities; hematuria and red cell casts.
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Wegener’s granulomatosis
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Like Wegener’s but lacks granulomas. P- or C-ANCA.
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Microscopic polyangiitis
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Vasculitis limited to kidney.
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1° pauci-immune crescentic glomerulonephritis
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Granulomatous vasculitis with eosinophilia. Involves lung, heart, skin, kidneys, nerves.
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Churg-Strauss Syndrome
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Often seen in atopic patients.
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Churg-Strauss Syndrome
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Acute, self-limiting disease of infants/kids.
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Kawasaki disease
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Acute, self-limiting disease of infants/kids. Acute necrotizing vasculitis of small/
medium-sized vessels. Fever, congested conjunctiva, changes in lips/oral mucosa, lymphadenitis. May develop coronary aneurysms. |
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Acute necrotizing vasculitis of small/medium-sized vessels. Fever, congested conjunctiva, changes in lips/oral mucosa, lymphadenitis. May develop coronary aneurysms.
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Kawasaki disease
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Acute, self-limiting disease of infants/kids. Acute necrotizing vasculitis of small/
medium-sized vessels. Fever, congested conjunctiva, changes in lips/oral mucosa, lymphadenitis. May develop coronary aneurysms. |
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Most common form of childhood systemic vasculitis.
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Henoch-Schönlein purpura
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Skin rash, arthralgia, intestinal hemorrhage, abdominal pain, and melena.
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Henoch-Schönlein purpura
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