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20 Cards in this Set

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A group of inflammatory pruritic skin disorders. Etiology: allergy (usually type IV hypersensitivity), chemical injury, or infection.
Dermatitis
Pruritic eruption, commonly on flexor surfaces. Often associated with other atopic diseases (asthma, allergic rhinitis).
Atopic dermatitis (eczema)
Type IV hypersensitivity reaction that follows exposure to allergen (poison ivy, poison oak, nickel, rubber, chemicals). Lesions occur at site of contact.
Allergic contact dermatitis
Epidermal hyperplasia (acanthosis) with parakeratotic scaling (nuclei still in stratum corneum) especially on knees and elbows. ↑ stratum spinosum, ↓ stratum granulosum. Auspitz sign.
Psoriasis
Auspitz sign
Psoriasis

-punctuate bleeding b/c you took off outer layer
Pruritic papules and vesicles. Associated with celiac disease.
Dermatitis herpetiformis
Pruritic, purple, polygonal papules; infiltrate of lymphocytes at dermoepidermal junction.
Lichen planus
Associated with infections, drugs, cancers, and autoimmune disease. Presents with
multiple types of lesions, including macules, papules, vesicles, and target lesions (red papules with a pale central area).
Erythema multiforme
Major form of Erythema multiforme
Stevens-Johnson syndrome is the major form of erythema multiforme. Characterized by high fever, bulla formation and necrosis, ulceration of skin, and a high mortality rate.
Flat, pigmented squamous epithelial proliferation with keratin-filled cysts (horn cysts).
Benign.
Seborrheic keratosis
Caused by sun exposure. Small, rough erythematous or brownish papules. Premalignant lesion. Risk of carcinoma is proportional to epithelial dysplasia.
Actinic keratosis
Tumor of connective tissue elements of dermis that causes raised, thickened scars.
Follows trauma to skin, especially in African-Americans.
Keloid
Autoimmune disorder with IgG antibody against epidermal basement membrane (linear immunofluorescence). Similar to but less severe than pemphigus vulgaris––affects skin but spares oral mucosa
Bullous pemphigoid
Potentially fatal autoimmune skin disorder. Intradermal bullae involving the oral mucosa and skin. Findings: acantholysis (breakdown of epithelial cell-to-cell junctions), IgG antibody against epidermal cell surface(immunofluorescence throughout epidermis)
Pemphigus vulgaris
_____ precursor to Squamous cell carcinoma
Actinic keratosis
Very common. Associated with excessive exposure to sunlight and arsenic exposure. Commonly appear on hands and face. Locally invasive, but rarely
metastasizes. Histopathology: keratin “pearls”
Squamous cell carcinoma
Most common in sun-exposed areas of body. Locally invasive, but almost never metastasizes. Gross pathology: pearly papules
Basal cell carcinoma
____ have “palisading” nuclei.
Basal cell carcinoma
______is a precursor to Melanoma
Dysplastic nevus
Common tumor with significant risk of metastasis. Associated with sunlight exposure; fair-skinned
persons are at ↑ risk. Incidence ↑. Depth of
tumor correlates with risk of metastasis
Melanoma