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53 Cards in this Set

  • Front
  • Back
What is best way to treat renal cell carcinoma?
Aldesleukin (Interleukin-2)
How do you treat metastatic melanoma?
Aldesleukin (IL-2)
What is best way to treat anemias during renal failure?
Give EPO.
What is MOA of filgrastim?
Granulocyte-colony stimulating factor (IL-3).

Granulocyte-macrophage colony stimulating factor: sargramostim.
This drug works as a G-CSF?
Filgrastim (early in alphabet)
This drug works as a GM-CSF?
Sargramostim (later in alphabet).
how do you treat kaposis sarcoma?
Interferon alpha
How you treat hepatitis B and C?
Interferon alpha.
How you treat malignant melanoma?
Interferon alpha
How you treat multiple sclerosis?
HOw you treat chronic granulomatous disease?
What IL can stimulate platelets?
This is a TNF-alpha antibody.
What can infliximab be used to treat?
1st: TNF-alpha antibody

Crohns disease, rheumatoid arthritis, ankylosing spondylitis.
This drugs inhibits calcineurin, cyclophilins, inhibiting IL-2 function.
What is cyclosporine used to treat?
Suppresses organ rejection after transplantation.
What is toxicity of cyclosporine?
Predisposition to infection and lymphoma. It is also nephrotoxic; preventable with mannitol diuresis.
What is tacrolimus?
This drug binds to FK-binding protein inhibiting IL-2 secretion.
What is MOA of muromonab (OKT3)?
directed against CD3 molecule of human T cells.
This drug is a TNF-alpah receptor that binds to TNF in the blood.

Use in RA, psoriasis, ankylosing spondylitis.
Name some opiod analgesics?
Which opiod analgesic does not cross BBB and can be used to treat cough?
What can opiod analgesics be used for?
1) Cough
2) Pain
3) Diarrhea (loperamide and diphenoxylate).
4) Pulmonary edema
What drug is used for maintenance problems for addicts?
What opiod is used for diarrhea treatment?
loperamide and diphenoxylate.
What are the toxicities of opioid analgesics?
Respiratory depression!!!


Miosis (Pinpoint pupils!!)
What is meperidine?
opiod analgesic.
What is fentanyl?
opiod analgesic
When taking fentanyl what symptoms do not develop tolerance to?
Constipation and Miosis!!!!
What are side effects of opiods refractory to tolerance?
Constipation and Miosis.
A patient comes in with heroin overdose. What is best way to treat this patient?
Naltrexone or naloxone (opiod receptor antagonist).
How do you treat opiod overdose?

What is contraindicated in morphine overdose?
oxygen because it can contribute even more to respiratory failure!!!
What is ibuprofen, Indomethacin, and Naproxen?
What is function of NSAIDS
inhibits both Cox-1 and Cox-2!!! This blocks prostaglandin synthesis. Reversibly (except
What are the clinical use of indomethacin?
Used to close a PDA!!
What can reversibly inhibit COX-1 and COX-2
What is MOA of acetominophen?
Inhibits COX reversiblly!! It gets inactivated peripherally, so it lacks anti-inflammatory properties!!!
What you treat acetominophen toxicity with?
N-acetylcysteine: antidote --> regenerates glutathione.
Compare acetominophen and aspiring?
Aspirin: irreversibly inhibits COX 1 and 2: has anti-inflammatory effects.

Acetominophen: reverisbly inhibits Cox 1 and 2: but no anti-inflammatory effects, because degraded peripherally!
Which COX is upregulated during inflammation?
COX-2: it is found in inflammatory cells and mediates inflammation and pain!!
What is MOA of celecobix?
COX-2 selective blocker. COX 2 is found in inflammatory cells and mediates inflammation and pain. It spares COX-1 which helps maintain gastric mucosa (through PGE2).
What is MOA of colchicine?
Depolmyerizes microtubules imparing luekocyte chemotoxasis and degranulation.
What is the first line treatment for gout?
Acutely, first line treatment should be pain relief. Once the diagnosis has been confirmed, the drugs of choice are indomethacin, other nonsteroidal anti-inflammatory drugs (NSAIDs),
What can be used to treat acute gout?
NSAIDS, indomethacin --> first line

What are the side effects of colchicine?
GI side effects.
What is used to treat chronic gout??
What is MOA of probenecid?
Inhibits reabsorption of uric acid, so more excreted.

2) prevents excretion of penicillin.

So probenecid: decreases urates and increases penicillins!!
What is MOA of allopurinol?
Inhibits xanthine oxidase, so decrease conversion of xanthine to uric acid. Also used in leukemia to prevent tumor lysis-associated nephropathy.
What effect do low dose aspirin have on gout?
It prevents the excretion of uric acid!!!
What effects do thiazides have on gout?
It causes hyperuricemia!!!