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15 Cards in this Set
- Front
- Back
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Corticosteroids
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Inhibit Phospholipase A2= ↓arachidonic acid
↓expression of COX-2 |
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Aspirin
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IRREVERSIBLE cycloxygenase inhibitor
low dose (<300mg/day): ↓platelet aggregation due to ↓TXA2 intermediate dose: antipyretic and analgesic high dose (>2400mg/day) anti-inflammatory Tox: GI, Acute Renal Failure, Interstitial Nephritis, Reye's syndrome in kids with viral infection |
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Ibuprofen
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NSAID: reversible COX-1 and COX-2 inhibitor
Tox:renal damage, fluid retetion, aplastic anemia, GI distress, ulcers |
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Naproxen
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NSAID: reversible COX-1 and COX-2 inhibitor
Tox:renal damage, fluid retetion, aplastic anemia, GI distress, ulcers |
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Indomethacin
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NSAID: reversible COX-1 and COX-2 inhibitor
Closes PDA, Acute Gout Tox:renal damage, fluid retetion, aplastic anemia, GI distress, ulcers |
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Ketorolac
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NSAID: reversible COX-1 and COX-2 inhibitor
Tox:renal damage, fluid retetion, aplastic anemia, GI distress, ulcers |
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Celecoxib
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Reversible COX-2 inhibitor; spares COX-1 which helps maintain gastric mucosa
Rheumatoid Arthritis, Osteoarthritis Tox: thrombosis, SULFA drug |
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Acetaminophen
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Reversible COX inhibitor- selective for mostly CNS; inactivated in periphery
Antipyretic, Analgesic, NO anti-inflammation use Tox: hepatic necrosis; depletes GLUTATHIONE Antidote: N-acetylcysteine |
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-DRONATE
Etidronate Pamidronate Alendronate Risedronate |
Bisphosphonates: inhibits osteoclast activity; reduces hydroxyapatite formation and resorption
Paget's disease, Osteoporosis, Malignancy-associated Hypercalcemia Tox: corrosive esophagitis, nausea, diarrhea |
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Colchine
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Prevents tubulin polymerization= no leukocyte degranulation
Acute Gout Tox: GI Indomethicin is less toxic |
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Probenicid
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Inhibits reabsorption of uric acid in Proximal Convoluted Tubule
CHRONIC Gout- for those with excretion problems Tox: inhibits secretion of penicillin |
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Allopurinol
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Inhibits Xanthine Oxidase= ↓conversion to uric acid
CHRONIC Gout, Lymphoma, Leukemia |
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Etanercept
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TNFα decoy reCEPTor (etanerCEPT)
Rheumatoid Arthritis, Psoriasis, Ankylosing Spondylitis |
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Infliximab
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Anti-TNFα Antibody
Rheumatoid Arthritis, Ankylosing Spondylitis, Crohn's Disease Tox: reactivation of TB |
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Adalimumab
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Binds TNFα
Rheumatoid Arthritis, Psoriasis, Ankylosing Spondylitis |
