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15 Cards in this Set
- Front
- Back
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Polymyalgia rheumatica
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pain and stiffness in shoulders and hips; often with fever, malaise and weight loss; does not cause muscular weakness; increased ESR; pts older than 50; associated with temporal arteritis
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polymyositis
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progressive systemic proximal muscle weakness caused by CD8 Tcell injury to myofibers; muscle biospy with evidence on inflammation is diagnostic
antiJo1 |
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dermatomyositis
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similar to polymyositis but also involves shawl and face skin rash and increased risk for malignancy
antiJo1 |
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MCTD
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Raynauds phenomenon, arthralgias, myalgias, fatigue, eso hypomotility
antibodies to U1RNP responds to steroids |
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Sjogrens syndrome
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xerophthalmia, xerostomia, arthritis
parotid enlargment increased risk of B cell lymphoma, dental caries autoantibodies to ribonucleoprotein antigens, SS-A (ro) and SS-b (la) predominantly affects females between 40 and 60 years old |
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SLE
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female; fever, fatigue, weight loss, nonbacterial verrucuous endocarditis, hilar adenopathy, and Raynauds
wire loop lesions with immune complex deposition in kidney |
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SLE sxs
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malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, serositis, renal problems, neuro, heme, immune
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SLE labs
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positive ANA
antibodies to dsDNA antiSm antihistone for drug induced positive VDRL |
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Gout
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precipitation of monosodium urate crystals into joints due to hyperuricemia which can be caused by LeschNyhan, PRPP excess, decreased excretion of uric acid or G6Patase def
thiazide and loop diuretics assymetric joint distribution crystals are needle shaped and negatively birefringent attacks after alcohol consumption or a large meal |
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Pseudogout
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caused by deposition of Ca pyrophosphate crystals within joint space
forms basophilic rhomboid crystals that are weakly positively birefringent usually affects LARGE joints no tx |
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sacroidosis
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granulomas (noncaseating), RA, Uveitis (ant or post), erythema nodosum, LAD, idiopathic, not tb, gamma globulinemia
ACE increase, increase in vit D |
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seronegative spondyloarthropathies
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assoc with HLA B27; ankylosing spondylitis (Bamboo spine), Reiters (urethritis, conjunctivitis and anterior uveitis), arthritis, Psoriatic arthritis, IBD arthritis
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scleroderma
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excessive fibrosis and collagen depsition throught the body
commonly sclerosis of skin but also of CV and GI systems and kidney |
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diffuse scleroderma
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widespread skin involvement, rapid progression, early visceral involvement, assoc with antiScl70 AB- topoisomerase I
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CREST
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calcinosis (subepithelial), raynauds, eso dysmotility, sclerodactyly, telangiectasia
often confined to fingers and face, more benign clincial course, anticentromere Ab |
