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15 Cards in this Set

  • Front
  • Back
Polymyalgia rheumatica
pain and stiffness in shoulders and hips; often with fever, malaise and weight loss; does not cause muscular weakness; increased ESR; pts older than 50; associated with temporal arteritis
progressive systemic proximal muscle weakness caused by CD8 Tcell injury to myofibers; muscle biospy with evidence on inflammation is diagnostic
similar to polymyositis but also involves shawl and face skin rash and increased risk for malignancy
Raynauds phenomenon, arthralgias, myalgias, fatigue, eso hypomotility
antibodies to U1RNP
responds to steroids
Sjogrens syndrome
xerophthalmia, xerostomia, arthritis
parotid enlargment increased risk of B cell lymphoma, dental caries
autoantibodies to ribonucleoprotein antigens, SS-A (ro) and SS-b (la)
predominantly affects females between 40 and 60 years old
female; fever, fatigue, weight loss, nonbacterial verrucuous endocarditis, hilar adenopathy, and Raynauds
wire loop lesions with immune complex deposition in kidney
SLE sxs
malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, serositis, renal problems, neuro, heme, immune
SLE labs
positive ANA
antibodies to dsDNA
antihistone for drug induced
positive VDRL
precipitation of monosodium urate crystals into joints due to hyperuricemia which can be caused by LeschNyhan, PRPP excess, decreased excretion of uric acid or G6Patase def
thiazide and loop diuretics
assymetric joint distribution
crystals are needle shaped and negatively birefringent
attacks after alcohol consumption or a large meal
caused by deposition of Ca pyrophosphate crystals within joint space
forms basophilic rhomboid crystals that are weakly positively birefringent
usually affects LARGE joints
no tx
granulomas (noncaseating), RA, Uveitis (ant or post), erythema nodosum, LAD, idiopathic, not tb, gamma globulinemia
ACE increase, increase in vit D
seronegative spondyloarthropathies
assoc with HLA B27; ankylosing spondylitis (Bamboo spine), Reiters (urethritis, conjunctivitis and anterior uveitis), arthritis, Psoriatic arthritis, IBD arthritis
excessive fibrosis and collagen depsition throught the body
commonly sclerosis of skin but also of CV and GI systems and kidney
diffuse scleroderma
widespread skin involvement, rapid progression, early visceral involvement, assoc with antiScl70 AB- topoisomerase I
calcinosis (subepithelial), raynauds, eso dysmotility, sclerodactyly, telangiectasia
often confined to fingers and face, more benign clincial course, anticentromere Ab