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32 Cards in this Set
- Front
- Back
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Centrally Acting Skeletal Muscle Relaxants
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baclofen carisoprodol chlorphenesin chlorzoxazone cyclobenzaprine metaxalone methocarbamol orphenadrine tizanidine
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Direct-Acting Skeletal Muscle Relaxants
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botulinum toxin type A botulinum toxin type B dantrolene
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Skeletal Muscle Relaxants.
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metaxalone . Baclofen is often used to relieve the muscle spasticity associated with cerebral palsy.Methocarbamol is the drug of choice if a child needs to be treated for tetanus.Dantrolene is used to treat upper motor neuron spasticity in children.
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Skeletal Muscle Relaxants..
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diazepam, which is a muscle relaxant and anxiolytic.
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Skeletal Muscle Relaxants…
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Carisoprodol is the centrally acting skeletal muscle relaxant of choice for older patients and for those with hepatic or renal impairment.
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Skeletal Muscle Relaxants…
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If dantrolene is required for an older patient, lower doses and more frequent monitoring are needed to assess for potential cardiac, respiratory, and liver toxicity.
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Skeletal Muscle Relaxants…
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Older women who are receiving hormone replacement therapy are at the same risk for development of hepatotoxicity as premenopausal women and should be monitored accordingly.
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control precise, intentional movement
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make up the pyramidal tract within the CNS
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coordinates unconsciously controlled muscle activity, and it allows the body to make automatic adjustments in posture or position and balance
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extrapyramidal tract
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baclofen (Lioresal)
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Muscle spasticity, spinal cord injuries
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carisoprodol (Soma)
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Relief of discomfort of acute musculoskeletal conditions in adults
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chlorphenesin (Malate)
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Relief of discomfort of acute musculoskeletal conditions
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chlorzoxazone (Paraflex)
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Relief of discomfort of acute musculoskeletal conditions in adults
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cyclobenzaprine (Flexeril)
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Relief of discomfort of acute musculoskeletal conditions in adults
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metaxalone (Skelaxin)
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Relief of discomfort of acute musculoskeletal conditions
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methocarbamol (Robaxin)
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Relief of discomfort of acute musculoskeletal conditions in adults; tetanus
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orphenadrine (Banflex, Flexoject)
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Relief of discomfort of acute musculoskeletal conditions in adults; quinidine-induced leg cramps (100 mg P0 at bedtime)
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tizanidine (Zanaflex)
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Relief of discomfort of acute musculoskeletal conditions in adults
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Direct-Acting Skeletal Muscle Relaxants
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or use in treating (general) spasticity that directly affects peripheral muscle contraction.
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Upper motor neuron-associated muscle spasticity; malignant hyperthermia
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dantrolene (Dantrium)
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botulinum toxin type A (Botox Cosmetic)
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Improvement of appearance in glabellar lines associated with corrugator or procerus muscle activity in adults; treatment of cervical dystonia; treatment of severe primary axillary hyperhydrosis; treatment of strabis-mus and blepharospasm associated with dystonia
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botulinum toxin type B (Myobloc)
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Reduction of severity of abnormal head position and neck pain associated with cervical dystonia
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The centrally acting skeletal muscle relaxants
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The centrally acting skeletal muscle relaxants work in the CNS to interfere with the reflexes that are causing the muscle spasm (Table 25.1). Because these drugs lyse or destroy spasm, they are often referred to as spasmolytics.
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All centrally acting skeletal muscle relaxants
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All centrally acting skeletal muscle relaxants should be used cautiously in the following circumstances: with a history of epilepsy because the CNS depression and imbalance caused by these drugs may exacerbate the seizure disorde
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