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16 Cards in this Set
- Front
- Back
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M1 receptors?
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Galpha q => increase IP3
autonomic ganglia, CNS |
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M2?
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Galpha i
cardiac inhibition and neural inhibition |
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M3?
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Galpha q
smooth muscle (GI tract, eye, airways, blood vessels) |
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M4?
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Galpha i
CNS |
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M5?
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Galpha q =>increased IP3
CNS, iris, cillary muscle |
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Muscarinic poisonisng? (DUMBBELS)
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Diarrhea
Urination Miosis (pin point pupils) Bradycardia Bronchospasms Emesis Lacrition Salivation |
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Bethanechol?
use, receptor |
Bladder and GI hypotonia (low muscle tone)
M3 |
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Pilocarpine?
Use |
Glaucoma
M3 (iris sphincter muscle contracts=>miosis, ciliary muscle contracts) improves drainage of AH |
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Oxotremorine?
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non-selective muscarinic agonist, parkisonism effects
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Atropine?
MOA, use, side effects |
muscarinic antagonist, penetrates BBB (stimulant, delitium, hallucinations)
Use - adjuct to anesthesia, treats anticholinesterase poisoining, bradycardia, asthma, parkinsons Side effects - urinary rentention, dry mouth, blurred vision, constipation |
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Scopolamine?
MOA, use, side effects |
MOA - non-selectve competative antagonist
Use - motion sickness, same as atropine side effects - sedation, ammnesia, same as atropine (dry mouth, urinary retention, blurred vision, constipation) |
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Pirenzepine?
MOA, use , side effects |
MOA - M1 selective antagonist, pariential cells, inhibits histimine release
Use - peptic ulcers no effect son SM and little on CNS side effcts- |
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Ipratropium?
MOA, use, side effects |
MOA - muscarinic antagonist
use - bronchospasms, asthma, COPD dosn't inhibit mucocilary clearance from bronchi |
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Darifenacin?
MOA, Use, side effects |
MOA - M3 antagonist, inhibit urination
Use - stress incontinace, hyperreflexia side effects - dry mouth, blurred vision, constipation |
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Oxybutynin?
MOa, use, side effects |
MOA - M3 antagonist, inhibit urination
Use - stress incontinace, hyperreflexia side effects - dry mouth, blurred vision, constipation |
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Tolteroidine?
MOA, use, side effcts |
MOA - M3 antagonist, inhibit urination
Use - stress incontinace, hyperreflexia side effects - dry mouth, blurred vision, constipation |
