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19 Cards in this Set

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acetylcholine
muscarinic agonist
bethanecol
muscarinic agonist

1. postsurgical atony after GI surgery
2. urinary retention - promotes voiding
pilocarpine
muscarinic agonist

1. glaucoma (although it has been replaced by prostaglandin inhibitors)
edrophonium
cholinesterase inhibitor (an alcohol one that is short-acting)

1. diagnosis of MG
2. evaluation of cholinergic status of MG patients
neostigmine
anticholinergic

1. postsurgery to reverse the effects of curare-like agents
2. MG

remember neogstigmine, pyridostigmine are quaternary, so you dont worry about cns s/e

physostigmine on the other hand is tertiary and can cross BBB
botulinum toxin
blocks ach vescicle fusion and therefore its release

1. dystonias
2. cosmetic
physostigmine
cholinesterase inhibitor

1. combat anticholinergic S/E of tricyclic antidepressants and antipsychotics
(physostigmine is tertiary and crosses the BBB)
rivastigmine
galantamine
donepazil
cholinesterase inhibitors

can cross BBB
used in AD treatment
pyridostigmine
cholinesterase inhibitor

1. MG treatment (drug of choice along with neostigmine)
malathion
irreversible cholinesterase inhibitor

insecticide
nerve gases (sarin, tabun)
irreversible cholinesterase inhibitor
echothiophate
irreversible cholinesterase inhibitor

does not cause aging of enzyme

1. narrow angle glaucoma (longer lasting than pilocarpine)
2. strabismus (strengthens weak extraocular muscle)
pralidoximine
pralidoximine = 2-PAM

antidote for nerve gas / malathion (insecticide) poisoning

pralidoximine is a nucleophile which binds the phosphorus in the irreversible cholinesterase inhibitor and removes it from the enzyme
atropine
muscarinic blocker
benztropine
muscarinic blocker

1. Parkinson's Disease

benztropine is very lipid soluble and can cross BBB

in PD, you have less dopamine, so Ach runs wild

block that Ach to decrease Sx
ipratropium
muscarinic blocker

1. COPD treatment. antimuscarinics help to stop bronchoconstriction and decrease secretions


tiotroprium used too
scopalamine
muscarinic blocker

1. motion sickness (scopolamine is lipid soluble and crosses BBB to exert its effect at muscarinic receptors within the vestibular system)
tropicamide
muscarinic blocker

1. used in eye exams to dilate the iris and stop accomodation
tiotroprium
muscarinic blocker

1. COPD therapy (ipratropium is used as well)