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19 Cards in this Set
- Front
- Back
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Multiple sclerosis is an autoimmune disease that attacks the...causing....and long term....
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Myelin...myelin disruption...axonal loss
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What cell mediates myelin damage in MS?
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T Cells
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What happens to the BBB in MS? Why?
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It becomes leaky. We don't know why.
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How is the T-cell thought to induce myelin damage?
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Cytokine secretion
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What happens to pre-myelinating oligiodendrocyte in MS?
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It never produces myelin, but they are viable.
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What kind of Dx is MS?
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A clinical one. Mostly based on history.
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18 yo WF presents with diploplia followed by vision loss in one eye. She has slurred speech and can no longer exercise like she used to. She has noticed a decreased preformance in school, and has a tough time playing softball. Recently she has felt numbness in her left hand. What is your dx?
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MS
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How can you predict by looking at an MRI how a pt with MS will present clincially?
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You can't tell. Most of the plaques/lesions are clinically silent.
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Can you dx MS with oligioclonal bands?
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no.
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Would it be a good idea for a person with MS to get a flu shot? why or why not?
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Sure. It is thought that flu virus can trigger MS.
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What is the primary way of preventing the progression of MS (Rx-wise)?
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Immune modulating agents
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What is the main way to control symptomatic MS?
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Steroids
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How do we rehabilitate MS pts.
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PT
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What do IFNs do for MS?
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Prevent proliferation of T-cells (INTERFERE with t-cell), stabilize BBB
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How does glatiramir acetate work?
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somehow drives the immune system in an anti-inflammatory direction. Can cross the BBB and be good for brain
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How does Mitoxantrone work?
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Knocks out T cells
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How does Natalizumab work? What is the issue?
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Blocks VCAM in brain...no crossing of T-cells. May cause progressive multifocal leukoencephalopath (PML...activation of JC Virus)
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What is Lhermitte's sign?
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Bend neck and feel shock
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What are used for parasthesias in MS?
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Anti-convulsants and anti-depressants
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