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11 Cards in this Set
- Front
- Back
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Quantitative trait loci?
Name one example |
The genetic loci that affect quantitative traits
Blood pressure |
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Haplotypes
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A set of closely linked alleles inherited as a unit
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Why do haplotypes exist?
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Crossing over occurs only about twice per chromosome per generation
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What happens to haplotypes over many generations?
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They decay
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How much of your genetic variation occurs outside of genes?
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2/3
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"Common" polymorphism
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>5% minor allele frequency
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Uncommon or infrequent polymorphism
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1-5% MAF
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Rare polymorphisms
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<1% of MAF
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Private polymorphisms
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Only seen in one patient or their family
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General ballpark numbers for rare, uncommon/infrequent, and common diseases?
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Rare: 1:1000-1:1,000,000
Uncommon: 1:100-1:1000 Common: 1:3-1:100 |
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BRCA1 and BRCA2
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BRCA1=More likely to have ovarian cancer
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