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15 Cards in this Set
- Front
- Back
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men or women affected by gout? |
90% men |
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the basic pathophys of gout is |
defective urate metabolism
can be either due to overproduction (more common) or underexcretion |
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some causes of overproduction |
idiopathic increased cell turnover enzyme deficiencies |
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examples of increased cell turnover to lead to gout |
cancer, hemolysis, psoriasis, chemotherapy |
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enzyme deficiencies that lead to gout |
Lesch Nyhan syndrome (HGPRT) GSDs |
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2 primary reasons for underexcretion of urate |
ketoacidosis lactic acidosis |
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what 2 drugs can lead to gout? |
thiazides (hyperGLUC) aspirin |
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classic presentation of gout is the |
podagra- extremely sudden, paainful inflammation the first MTP joint |
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tissue deposits of urate crystals with foreign body reaction |
tophi |
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places that tophi can develop |
kidneys subcu bone cartilage |
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Long asymptomatic periods without attacks is also |
common |
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the most accurate test for gout is |
aspiration of the affected joint
negative birefringent needle-shaped crystals on microscopy |
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Is the WBC abnormal in the joint? |
yes it shows WBC from 2k to 50k usually
mostly neutrophils, but not as significant as a septic joint |
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Do you have to tap the joint to confirm a dx of gout? |
YES- you have to exclude infection |
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What % of patients with an acute flare of gout have a normal uric acid level? |
25% |
