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10 Cards in this Set

  • Front
  • Back
What is gout?
- Painful form of arthritis
- Uric acid build-up
Who does gout affect?
Mostly middle-aged to elderly men and postmenopausal women
What are the the therapeutic goals of treating gout?
- Increase excretion of uric acid
- Inhibit inflammatory cells
- Inhibit uric acid biosynthesis
- Provide symptomatic relief (typically w/ NSAIDS or steroids)
How are NSAIDs used to treat gout? Which ones?
- Within 24 hours to decrease inflammation d/t uric acid crystals
- E.g., Indomethacin, naproxen, ibuprofen (BUT NOT aspirin)
- Consider side effects (esp. GI)
When are steroids used to treat gout?
- Symptomatic relief for patients that can't take NSAIDs
- Only short-term use d/t side effects
What is Rheumatoid Arthritis?
- Second most common form of chronic arthritis
- Affects 1% of adult population worldwide
- Potentially crippling disease, significantly compromises quality of life in affected patients
- Inflammatory dz of unknown etiology
What does Rheumatoid Arthritis target in the body?
Synovium of joints (involves activated T cells, TNFalpha, IL-1)
What are the the therapeutic goals of treating rheumatoid arthritis?
- Relieve pain
- Reduce inflammation
- Slow down or stop joint damage
- Improve a person's sense of well-being and ability to function
How are NSAIDs used to treat Rheumatoid Arthritis?
- Symptomatic relief, but you need long duration of treatment w/ large doses
- No effect on progression of disease
- Relieves symptom of pain
- Beware of GI problems
What are biological response modifiers?
Protein therapeutics designed mostly to target cytokines and cell-surface molecules