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10 Cards in this Set
- Front
- Back
What is gout?
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- Painful form of arthritis
- Uric acid build-up |
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Who does gout affect?
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Mostly middle-aged to elderly men and postmenopausal women
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What are the the therapeutic goals of treating gout?
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- Increase excretion of uric acid
- Inhibit inflammatory cells - Inhibit uric acid biosynthesis - Provide symptomatic relief (typically w/ NSAIDS or steroids) |
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How are NSAIDs used to treat gout? Which ones?
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- Within 24 hours to decrease inflammation d/t uric acid crystals
- E.g., Indomethacin, naproxen, ibuprofen (BUT NOT aspirin) - Consider side effects (esp. GI) |
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When are steroids used to treat gout?
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- Symptomatic relief for patients that can't take NSAIDs
- Only short-term use d/t side effects |
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What is Rheumatoid Arthritis?
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- Second most common form of chronic arthritis
- Affects 1% of adult population worldwide - Potentially crippling disease, significantly compromises quality of life in affected patients - Inflammatory dz of unknown etiology |
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What does Rheumatoid Arthritis target in the body?
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Synovium of joints (involves activated T cells, TNFalpha, IL-1)
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What are the the therapeutic goals of treating rheumatoid arthritis?
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- Relieve pain
- Reduce inflammation - Slow down or stop joint damage - Improve a person's sense of well-being and ability to function |
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How are NSAIDs used to treat Rheumatoid Arthritis?
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- Symptomatic relief, but you need long duration of treatment w/ large doses
- No effect on progression of disease - Relieves symptom of pain - Beware of GI problems |
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What are biological response modifiers?
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Protein therapeutics designed mostly to target cytokines and cell-surface molecules
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