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9 Cards in this Set
- Front
- Back
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What hormones are anabolic for bone?
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Progesterone, testosterone, PTH
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T or F
Aside from the conventional nuclear progesterone (PG) receptors there may be surface receptors? |
True. These surface receptors may respond more quickly to PG (via IP3, DAG and an increase in Ca)
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Which cell line does Progesterone stimulate?
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Thats right! Osteoblasts, not osteocytes.
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What does PG stimulate osteoblasts to do?
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Proliferate, differentiate and produce growth factors. (ie favors new bone formation)
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What does PG stimulate the production of?
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alkaline phosphatase and osteocalcin
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T or F
Progesterone affects RANKL and OPG synthesis. |
False. PG has no effect on these, unlike estrogen.
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What inactivates progesterone?
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Osteoblasts rapidly inactivate PG, which may impact the PG mediated effects.
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T or F
Estrogen cannot protect against osteoporosis when progesterone is absent. |
True.
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In males which hormone has similar effects to progesterone in terms of bone formation?
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Testosterone.
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