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16 Cards in this Set

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hallmark of SLE
Ig to nucleic acids, esp DNA
Sx in SLE
"I'M DAMN SHARP": Must have 4:

I=ImCo
M=Malar Rash
D=Discoid Rash
A=ANA
M=Mucositis (i.e. oral ulcers)
N=Neurologic Prob
S=Serositis (Pluritis/Pericarditis)
H=Hematologic
A=Arthritis
R=Renal
P=Photosensitivity
is arthritis erosive in SLE?
no (vs RA)
genetics in SLE
-polygenic; possibly chromosome 1 involved
malar vs discoid rash
discoid rash heals
WITH SCARRING &
SKIN ATROPHY
ex of heart problems in SLE?
-Libman Sachs sterile vegetarions on mitral valves
-pericarditis
MCC of deaeth in SLE
MI (d/t arteriosclerosis of coronary arteries)
autoantibodies in SLE
1.ANA
-seen in 95% of SLE
-not specific for ANA

4 patterns:
rim or outline-->DNA,
*ONLY IN LUPUS
speckled-->ribonuclear proteins
*SCLERODERMA
nucleolar-->4S RNA,
*SCLERODERMA
diffuse-->RNA, DNA, histones, proteins
ANA: rim or outline pattern indicates ?
DNA
*only in lupus
ANA: speckled pattern indicates?
ribonucelar proteins
*SCLERODERMA
ANA: nucleolar pattern suggests
4S RNA
*SCLERODERMA
ANA: diffuse pattern?
not helpful,
RNA, DNA, histones, proteins
what AutoAb is highly specific for SLE?
Anti-Sm (Smith) is highly spec for SLE"

if you have Anti-Sm, you have lupus!
why are anti-SSA antibodies bad?
SSA Ag is most prominetn for developing fetal heart,

if IgG binds SSA-->congenital heart malformation or neonatal complete heart block
Tx lupus
corticosteroids (for serositis: pleuritis and pericarditis)

Renal: cyclophosphamid + mycophenolate mofenil

Skin: hydroxycloroquine
what kills SLE pts?
early deaths d/t SLE or infxn

later deals d/t corticosteroid-induced atherosclerosis