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22 Cards in this Set

  • Front
  • Back
- low absolue amount of bone
- osteoporosis and osteomalacia
low turnover osteoporosis
- normal number of BMUs
- impaired blast recruitment
- age-related kind
how exactly does PTH increase bone resorption?
- directly stimulates blasts
- the basts then do the clast activating factor
- so high turnover osteoporosis
- subperiosteal bone resorption and w/ cystic lesions, or brown tumors
what is going on w/ Ca and P in 1o hyperPT
- high serum Ca, low serum P
- Ca taken from bone
- P excretion increased
- Ca excretion increased from big filtered load
what are the Sx of hyper PT?
- stones (Ca kidney stones)
- bones (bone pain from more resorption and lesions)
- groans (general malise)
- usually no skeletal abnormalities
- from removal of thyroid
- decreased Ca and increased P
- PTH resistance
- PTH is high, but it isn't doing anything
- low Ca, high P
Albright hereditary osteodystrophy
- from pseudohypPT
- short stature
- round facies
- shortened ring fingers
Causes of 1,25-D deficiency
- poor diet
- GI malabsorption
- renal failure (no 2o OH)
- lack of sun (rare)
what happens when the Ca P product is less than 30?
osteomalacia (there is no mineralization)
looser zones
- from ricketts
- pseudofractures that are radiolucent lines perpendicular to the bone cortex
renal osteodystrophy
- at first, it cant get rid of P, and it can't make 1,25-D so PTH is stiumlated (2o hyperPT)
- so P is really high, but Ca is really low, so product less than 30 and osteomalacia
- when GFR gets below 25%, P even higher, so product more than 30, and osteoscleorsis
- combo of 2o hyperPT, osteomalacia, and osteosclerosis
2 categories of 1o osteoporosis
- juvenile (v. rare)
- involutional (type 1 and type 2)
type 1 involutional osteoporosis
- women 5-20 yrs post-menopause
- greater loss of trabecular bone
- high turnover
- vertebral and colles fractures
type 2 involutional osteoporosis
- low turnover
- men and women
- vertebral and prox femur fractures
steroid-induced osteoporosis
- high turnover
- 2o hyperPT from low Ca gut absorption and renal resorption
hyperthyroid osteoporosis
- high turnover
- HT initiates blasts, which then initiates clasts
1o defect in blast function, so abnormal extracellular glycoproteins
osteogenesis imperfecta type 1 and 2
- inability to make type I collagen
- AD most common, mildest
- type II more severe, die as prenates
osteopetrosis does what to the immune system?
it decreases it b/c the marrow cavity is narrowed
paget disease
- AD, or viral factor
- LOTS of bone turnover, usually localized
- bone is mixture of immature, women and matrue, lamellar
- AP is way up - Ca and P are normal
Acromegaly and bone
- too much GH
- high turnover osteopenia
- but it also stiumates the periosteium
- one of the few diseases where the periosteium is big in adults