Msi Week 2: Tolerance Hill

Front 1

Unresponsiveness by lymphocytes to self antigens

Back 1

Immunologic tolerance

Front 2

Tolerance induced in primary lymphoid organs

Back 2

Central tolerance

Front 3

Tolerance induced in peripheral tissues

Back 3

Peripheral tolerance

Front 4

Apoptosis of immature lymphocytes due to strong interaction with self peptides

Back 4

Negative selection/deletion

Front 5

T cell population that arises from recognition of self-antigen

Back 5

Regulatory T cells

Front 6

Markers of T regulatory cells

Back 6

CD25 & Foxp3

Front 7

Mechanisms of T regulatory cell-mediated inhibition of T cell responses

Back 7

Inhibit T cell activation or effector functions
(by releasing TGF-B and IL-10)

Front 8

Functional inactivation of T cells when exposed to antigen without co-stimulation

Back 8

Anergy

Front 9

Inhibitory receptors that maintain inactivity of autoreactive T cells

Back 9

CTLA-4
(results in anergy)

Front 10

Apoptosis of mature lymphocytes that recognize self peptides

Back 10

Deletion/activation-induced cell death

Front 11

Mechanisms of apoptosis in activation-induced cell death

Back 11

Pro-apoptotic proteins or Fas-FasL interaction

Front 12

Expression of new light chain in B cells after recognition of self antigens

Back 12

Receptor editing

Front 13

Immune response against self antigens

Back 13

Autoimmunity

Front 14

Factors that contribute to development of autoimmunity

Back 14

Genetics & Environment

Front 15

Chance of autoimmunity in individual who inherits a particular HLA allele compared with one who does not

Back 15

Relative risk

Front 16

Defect in this gene results in autoimmune polyendocrine syndrome

Back 16

Autoimmune regulator (AIRE)

Front 17

Defect in these serum proteins results in lupus-like disease

Back 17

C2 & C4

Front 18

Defect in this gene results in X-linked polyendocrinopathy and enteropathy (IPEX)

Back 18

Foxp3

Front 19

Defect in these genes results in autoimmune lymphoproliferative syndrome

Back 19

Fas/FasL

Front 20

Similarity between microbial and self antigens

Back 20

Molecular mimicry

Front 21

Types of antigens that activate large numbers of T cells without binding to antigen recognition site of the TCR

Back 21

Superantigens

Front 22

Mechanism by which infection may “break” T cell anergy

Back 22

Inducing co-stimulators on local APCs

Front 23

Tissues/organs normally sequestered from immune response (immune privileged sites)

Back 23

Eye, testes, ovary, brain

Front 24

Type of antigen present in primary lymphoid tissue

Back 24

Tolerogenic self antigens

Front 25

Type of antigen typically presented to lymphocytes without second signals

Back 25

Tolerogenic self antigens

Front 26

Type of antigen typically present throughout life

Back 26

Tolerogenic self antigen

Front 27

Type of antigen typically present in peripheral lymphoid tissue

Back 27

Immunogenic foreign antigens

Front 28

Type of antigen typically presented to lymphocytes with second signals

Back 28

Immunogenic foreign antigens

Front 29

Type of antigen typically short-lived and eliminated by immune response

Back 29

Immunogenic foreign antigens

Front 30

Route of administration of an antigen most likely to induce tolerance

Back 30

Orally

Front 31

Route of administration of an antigen most likely to induce an immune response

Back 31

Subcutaneous or intramuscular