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17 Cards in this Set
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Avonex (interferon beta-1a) |
Dose: 30 mcg/wk IM SE: HA, flu-like sx, usually temp; can be prevented /managed LABS: Liver enzymes, blood count, neutralizing antibodies |
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Betaseron (interferon beta - 1b) |
Dose: 250 mcg/EOD SQ SE: flu-like sx, injection site rx, blood count & liver function, usually temp, can be prevented /managed LABS: Liver enzymes, blood count, neutralizing antibodies |
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Copaxone (glatiramer acetate) |
Dose: 20 mg/day or 40 mg/3xWK SQ SE: injection site, systemic 1 in 10% (5-15 min after, anxiety, flushing, chest tightness, dizziness, palpitations, SOB) last a few min & no tx or long lasting effects
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Extavia (interferon beta - 1b) |
Dose: 250 mcg/EOD SQ SE: flu-like sx, injection-site rx, blood count, liver enzymes (usually temp, prevented/managed) LABS: Liver enzymes, blood counts, neutralizing antibodies. |
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Interferon beta-1a |
Immune system modulator w/ antiviral properties |
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Interferon beta-1b |
Immune system modulator w/ antiviral properties. |
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Glatiramer Acetate |
Synthetic chain of four amino acids found in myelin (immune system modulator that blocks attacks on myelin) |
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Alemtuzumab |
Humanized monoclonal antibody that rapidly depletes or suppresses T&B cells which can damage the myelin & nerves of the CNS |
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Antineoplastic |
Immune system modulator & supressor |
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Natalizumab |
Humanized monoclonal antibody that inhibits adhesion molecules; thought to prevent damaging immune cells from crossing the blood-brain barrier. |
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Teriflunomide |
Immunomodulator affecting the production of T&B cells; may also inhibit nerve degeneration |
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Fingolimod, FTY720 |
S1P-receptor modulator that blocks potentially damaging T cells from leaving the lymph nodes. |
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Dimethyl fumarate |
Immunomodulator w/ anti-inflammatory properties; may have neuroprotective effects, potentially protecting the nerves & myelin coverage from damage |
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Glatopa (glatiramer acetate) |
Dose: 20 mg/day SQ SE: Injection site, systemic 1 in 10% (5-15 min after, anxiety, flushing, chest tightness, dizziness, palpitations, SOB) last a few min & no tx or long lasting effects |
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Plegridy (interferon beta - 1a) |
Dose: 125 mcg/every 2 wks SQ SE: Flu-like, temporary, prevented/ managed. LABS: Liver enzymes, blood counts, neutralizing antibodies. |
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Rebif (Interferon beta-1a) |
Dose: 44 mcg/3xWK SQ SE: Flu-like sx, injection-site rx, blood count & liver enzyme abnormalities, usually temporary, prevented/managed. LABS: Liver enzymes, blood counts, neutralizing antibodies. |
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Neutralizing Antibodies |
A form of antibody that reacts with an infectious agent (usually a virus) and destroys or inhibits its infectivity and virulence; may be demonstrated by means of mixing serum with the suspension of infectious agent, and then injecting the mixture into animals or cell cultures that are susceptible to the agent in question. |
