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16 Cards in this Set
- Front
- Back
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where are herberden nodes found?
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DIP, in osteoarthritis
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where are bouchard's nodes found?
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PIP, in osteoarthritis
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Describe osteoarthritis pathogenesis
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degeneration or loss of articular cartilage,progressive chondrocyte injury and drop off over time
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What is RF?
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rheumatoid factor- IgM autoantibody against Fc fragment of IgG, circulates to form immune complexes
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How does gout come about, the pathogenesis basically?
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overproduction or underexcretion (most common) of uric acid, uric acid end product of purine synthesisi
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Pseudogout, how would you dx?
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see calcium pyrophosphate crystals, POSITVELY birefrigent crystals
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Presentation and findings for Duchenne muscular dystrophy
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normal at birth but weak by age 5, starts at pelvic girdle but spreads to shoulder girdle. mutation in gene coding for dystrophin
histo- increased number of internal nuclie, degenration and variation in fibers |
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two diseases that have defect in xp21 gene encoding for dystrophin?
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becker and duchene MD
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presentation and findings of becker MD?
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later in childrood and slower than duchenne muscular dystrophy
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pathophysiolgoy and presentation of M. gravis?
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autoabs against Ach receptor, presents following immune-related injury- easy fatiguing, ptosis, diplopia
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clinical and x-ray findings of paget disease?
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lion facies, fractures, increased head size
see moasic pattern of lamellar bone |
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osteoid osteoma, describe?
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benign painful growth of long bone, pain worst at night,,,,relieved by ASPIRIN
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x-ray for osteoid osteoma?
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central radiolucency surrouned by sclerotic rim
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x ray findings for osteosarcoma?
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codmans triangle- periosteal elevation, sunburst pattern
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lipoma- clinical findings and microscopic findings?
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benign tumor of fat, see delicate reticulin network, each lipocyte completely encircled by reticulin
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microscopic findings of liposarcoma?
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lipoblasts- contain clear cytoplasmic vacuoles that scallop the nucleus
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