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22 Cards in this Set
- Front
- Back
define demyelination?
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myelin destruction out of proportion to axonal damage
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What is acute disseminated encephalomyelitis? How treat? Optic Neuritis?
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a single episode of widespread inflammation; treat underlying infections agent/source of inflamm
Optic Nuer- only example of demyelination at a single site |
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MS..Clinical symptoms? 3
Sensory symptoms? |
Ambulatory problems- loss of spinal cord myelin
Visual Problems- loss os optic nerve INO- loss of MLF and vestibular reflex Parathesias and loss of pain/temp in asymetric patterns |
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Etiology of MS: viral or env?
explain in context of epidem genetic vs env? |
thought to be EBV or Vit D def, since high prevalence in northern latitudes and northern hemispheres and W>M 2:1
Large genetic influence, but needs trigger env. |
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What are oligoclonal bands? How is CT used in diagnosis?
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Oligoclonal bands are when plasma cells make specific ABs to CNS anitgens ** only in MS***
CT- get contrast enhancing images (white blobs- plaques) and also see brain atrophy |
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MS; what causes the early prodromal symptoms and what leads to to later stages of disease? Implications for Early therapy?
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Early- immune mediated problem that leads to demyelination
Later- CNS degeneration of brain atrophy and axonal loss Treat early with Immunosuppressives (decrease lymphocyte recruitment |
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What is a neurogenic disease? Explain denervation/renervation and how muscle fiber types can change? WHat are type 1? Type 2a and Type 2b?
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Deterioration of nerve. Get reinnervation by collateral nerves and it alters the type of nerve fiber. Go from mixed assortment to regionally identified based on collateral sprouting.
type 1= slow oxidative type 2a= fast oxidative/glycolytic type 2b= fast glycolytic |
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What is MG?
3 other ways to see muscle pathology |
autoABs to the ACHr at NMJs
Primary muscle diseases DuChennes myopathies associated with toxins/drugs or vasculitis |
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What is polymyositis? How differ from Dermatomyocytis?
How same? |
POLY- **Actual PMN infiltration of muscles; muscle fibers necrose and regenerate
DERMATO- perifascicular atrophy, NO Infiltration Both- proximal muscle weakness and rash |
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Inclusion Body Myositis?
Duchenne's; epi, pathogenesis, what happens molecularly? Long temr prognosis? |
rimmed vacuoles that appear in muscle fibers
Duchennes- 1/3500 boys; mutation in Dystrophin gene; degeneration and replacement with connective and fatty tissue; lose plasma membrane.. end up in wheelchairs by teenage years. |
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Circadian clock; what cells in retina? where is "Master Clock"? What based on? Input from all over body?
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Melanopsin cells in retina; project to the superchiasmatic nucleus in hypothalamus; have circadian clocks all throughout body, but master integrates them all; based on 24 hr rotation of earth
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What is the homeostatic system for sleep and its relation to circadian rythm?
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Homeostatic- increased pressure to go to sleep the moment we wake up; but circadian rythm can overcome that force; as 16 wake hrs approaches, homeostatic drive takes over
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What occurs cognitively after 16/18 wake hours? When we are tired, what is the first to go somatically?
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State instability- delays in brain's response
Eye Movements become slow (CN 3,4,6) |
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Sleep stages? how many?
onger we've been awake, what about staging? |
4 Non-rem and I rem; the longer we've been awake, the greater demand for more sleep and we have decreased latencies and go right into stage 1/2
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4 facts about sleep (look at)
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1. Env factors DONT cause sleepiness..just inattention
2. Individuals vary in their reaction to sleep loss, but can't accurately judge it 3. Humans need 7-9 hrs for optimal performance. Leads to sleep debt that must be made up. 4. WE biologically NEED sleep. Don't adapt to less of it. |
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Vulnerability to the cognitive effects (dim accuracy/speed) of sleep deprivation? Type 1? vs Type 3?
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Type 1 = MED Students; cognitively resistant to sleep deprivation
Type 3- vulnerable to sleep depriv |
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3 major complaints of sleeping issues?
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1.. I can't sleep.. Insomnia
2. I sleep too much. Narcolepsy 3. I do weird things in my sleep- Parasomnias |
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Narcolepsy: epi, onset age, sleep architecture boundaries?
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.o5%, 20/30's first DX; boundaries between wakefulness and REM sleep all day
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Clinical features of narcolepsy? What is cataplexy?
TX of Narcolepsy? |
excessive sleepiness, constanly in REM, vivid dreams
Cataplexy= loss of muscle tone; head bobbles; feel weak upon wakening TX= SSRI's and stimulants |
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Parasomnias
1. Disorders of arousal? What boundary between? What are the symptoms 2? |
Wake up out of slow wave NREM/WAKE.
Sleep walk- do something purposeful, but don't realize it. Sleep Terror- wake up and are scared shitless; people don't recall, but generally outgrow it |
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Parasomnia:
2. Treatening Dream disorder? Clinical? REM or NREM? What associated highly with? |
Fall out of bed and punch wife/injury self; defense in a dream
REM/WAKE issue Can be scene with drug intoxication/withdrawal High association with Alzheimer's |
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Parasomnias: Restless Leg syndrome vs. Periodic Limb movements? How differ? Causes/family Hx?
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Restless leg- a VOLUNTARY motor response due to a sensory disturbance; strong family history and caused by DOPA fluctuations
Periodic Limb Movements: INVOLUNTARY sleep relted motor phenomenon due to loss of supra-spinal inhibition during sleep |