Movement Disorders Pharm

Front 1

Reserpine

Back 1

Depletes NT formation and creates iatrogenic Parkinsons

Front 2

Deprenyl

Back 2

MAO-B Inhibitor protective against MPTP toxicity

Front 3

Levodopa

Back 3

Prodrug for DA- decarboxylated in nerve terminal
Uses AA transporters to be absorbed in gut and across BBB
T1/2 is 1-3 hrs.
Not long term therapy because over time neurons can't store DA
Wearing off and On/Off effect

Front 4

Domperidone

Back 4

Peripheral DA antagonist used for treating N&V associated with Levodopa therapy

Front 5

Clozapine

Back 5

AP used for treating behavioral changes associated with Levodopa therapy

Front 6

Carbidopa

Back 6

Blocks peripheral Dopa Decarboxylase
Fewer peripheral SEs of Ldopa therapy like orthostatic hypotension and arrythmias (In periphery DA is vasorelaxive and increases CO/BP)

Front 7

Selegiline

Back 7

MAO-B inhibitor that blocks DA metabolism in the brain
Amphetamine metabolites give it abuse potential

Front 8

Rasagiline

Back 8

MAO-B inhibitor that blocks DA metabolism in the brain
No amphetamine metabolites so no abuse potential

Front 9

Trihexiphenidyl, Benztropine, Biperiden and Procyclidine

Back 9

Antimuscarinics that work in striatum used to treat symptoms of PD like tremor and drooling

Front 10

Diphenhydramine

Back 10

Weak central anticholinergic drugs used to treat symptoms of PD without antimuscarinic effects

Front 11

Amantidine

Back 11

Increases DA release and possesses anticholinergic activity so exacerbates anticholinergic side effects when used together

Front 12

Bromocriptine and Pergolide

Back 12

Ergots
Bromocriptine is full D2 agonist and partial D1 agonist
Pergolide is full D1 and D2 agonist
treat "on/off" effect of Levodopa; can use with or as alternative to levodopa- no enzyme conversion needed, longer duration, avoid free radical production

Front 13

Pramipexole and Ropirinole

Back 13

Full D2 and D3 agonists that are associated with compulsive behavior
Used to treat RLS

Front 14

Entacapone

Back 14

COMT Inhibitor
Inhibits metabolism of LDopa peripherally as opposed to Selegeline that inhibits brain metabolism of Da
Decreases "wearing off" effect

Front 15

Treatment for Huntingtons

Back 15

Reserpine and Tetrabenzamine
Deplete catecholamines
Hypotension and Depression
Avoid drugs with anticholinergic SEs

Front 16

Baclofen

Back 16

GABA agonist that works as a muscle relaxant to treat symptoms of spasticity in ALS

Front 17

Riluzole

Back 17

Inhibits Glutamate release and may increase survival time in ALS patients

Front 18

Tourettes Treatment

Back 18

Alpha Adrenergic agonists Clonidine and Guanfacine
Risperidone