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14 Cards in this Set

  • Front
  • Back
Morphine Presentation
10mg in 1ml amp
Mophine Pharmacology
A Narcotic analgesic

Morphine Actions - CNS Effects

Depression (leading to analgesia)




Respiratory depression




Depression of cough reflex




Stimulation (changes of mood, euphoria or dysphoria, vomiting, pin- point pupils)




Dependence (addiction)

Morphine Actions - Cardiovascular Effects

Vasodilatation




Decreases conduction velocity through the A-V Node

Morphine Metabolism
By the liver and excreted by the kidneys
Morphine Primary Emergency Indications
1. Pain relief



2. Sedation to maintain intubation




3. Sedation facilitate intubation (where fentanyl


not appropriate for RSI - modified or


Paediatric IFS)

Morphine Contraindications
1. History of hypersensitivity



2. Renal impairment / failure




3. Late second stage of labour

Morphine Precuations
1. Elderly patients
2. Hypotension
3. Respiratory depression
4. Current asthma
5. Respiratory tract burns
6. Known addiction to opioids
7. Acute alcoholism
8. Pts on monoamine oxidase inhibitors
Morphine Route of Administration
1. Intravenous


2. Intramuscular



3. Subcutaneous

Morphine Side Effects CNS
1. Drowsiness

2. Respiratory depression
3. Euphoria
4. Nausea, vomiting
5. Pin-point pupils
6. Addiction


Morphine Side Effects CNS

1. Hypotension




2. Bradycardia

Morphine Special Notes
Morphine sulphate is a schedule 8 drug under the poisons act and its use must be carefully controlled with accountability and responsibility.

Side effects of morphine sulphate can be

reversed with naloxon.

Occasionally wheals are seen in the line of the vein being used for IV injection. This is not an allergy, only a histamine release.

Morphine Times IV

Onset 2-5 minutes


Peak 10 minutes



Duration 1-2 hours

Morphine Times IM
Onset: 10-30 mins
Peak: 30-60 mins
Duration: 1 - 2 hrs