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13 Cards in this Set

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Clomiphene
INFERTILITY

Competitive antagonist of the estrogen receptor (BOTH ERa & b)

Artifically INDUCES ovulation therefore good for INFERTILITY

Block estrogen-mediated negative feedback in the pituitary
Raloxifene
Treat Breast Cancer

Estrogen agonist in the BONE

Does not have agonistic activity in the uterus

used mainly to prevent OSTEOPOROSIS
Tamoxifen
Breast Cancer treatment

may be used PROPHYLACTICALLY

Estrogen receptor antagonist in the breast; agonist in the endometrium

cease use after 5 years to avoid drug-resistant breast tumors

SE: ENDOMETRIAL BLEEDING, uterine cancer
Mifepristone
RU-486

Abortifacient for the 1st trimester
Leuprolide
Analog of GnRH

With chronic administration v pituitary gonadotropin production (after initial increase)
Finasteride
Prostatic Hyperplasia

5A-reductase inhibitor

Antiandrogen

B/c prostate growth is dependent on DHT rather than testosterone
Danazol
Synthetic steroid ethisterone

A modified testosterone

used to treat ENDOMETRIOSIS
Norethindrone
Synthetic progestin

Hormonal contraceptive

only active in the presence of estrogen and the primed estrogen system
The 3 Adrenal Zones and their products (from capsule to medulla)?
Zona Glomerulose - aldosterone

Zona Fasciculata - cortisol

Zona Reticularis - androgens
Fludrocortisone acetate
GLUCOCORTICOID (cortisol-like) & MINERALOCORTICOID (aldosterone-like) activity
Difference b/w NSAIDs and Glucocorticoids
Glucocorticoids also inhibit leukocytes and macrophages that contribute heavily to inflammation
Aminoglutethimide
Inhibits the synthesis of all hormonally active steroids

Blocks the conversion of cholesterol to pregnenolone

Used to reduce glucocorticoid levels in patients with Cushing's as well as other things such as prostate and breast cancer
Benefit of Aromatase Inhibitors over Tamoxifen?
Aromatase Inhibitors do not increase the risk of uterine cancer or venous thromboembolism