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103 Cards in this Set
- Front
- Back
Phenothiazine
1. What is it 2. 2 kinds |
traditional antipsychotic
1. Most prescribed neuroleptic to control positive symptoms 2. Includes chlorpromazine (aka Thorazine) and Fluphenazine (aka Prolixin or Permitil) |
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What's bad about Haloperidol
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Haldol
Most severe extrapyrimidal symptoms |
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NMS- Nauroleptic malignant syndrome
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1. SE of antipsychotics
Rapid onset of motor, mental, and autonomic symptoms, like muscle rigidity, tachycardia, hyperthermia, and altered consciousness 2. FATAL if drugs aren't immediately stopped |
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Tardive Dyskenesia
1. What is it 2. Who gets it 3. What's it similar to 4. What alleviates it |
1. Extrapyramidal SE
2. More common in females and elderly 3. Similar to Huntingtons 4. Alleviated by giving a benzo |
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Huntingtons Chorea
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Involuntary jerky movements of the face, arms and trunk
Symptoms look like TD |
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Resperidone
1. What is it 2. Problem |
1. Popular atypical antipsychotic
2. Slower onset than traditional antipsychotics |
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TCA's
1. How do they work 2. What depression symptoms do they treat? 3. What are other uses (5) |
1. Block the reuptake of norepinephrine, dopamine and/or serotonin at the nerve synapses
2. Vegetative and somatic symptoms of depression - weight loss, sleep disturbances,etc. 3. Panic Disorder, Agoraphobia, OCD, Bulimia and enuresis |
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Atypical antipsychotics
1. What do they do? 2. How 3. Why better than TCAs |
1.Treat positive and negative schizophrenia
2. Block dopamine (especially D4)and serotonin 3. No TD, less EPS |
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Anticholinergic SEs
1. What are they 2. How long does tolerance take? |
1. Blurred vision, urinary retention, constipation, dry mouth, sexual dysfunction, confusion
2. Tolerance within a few weeks to months |
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What are Olanzepine, Respiridone and Quietapine?
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Atypical antipsychotics
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Clozapine
1. What is it 2. How does it work 3. Other uses (3) |
1. Clozaril
Atypical antipsychotic 2. Acts on D4 and other dopamine receptors 3. Alcohol/drug addictions, Bipolar, Motor symptoms of Huntingtons, Parkinsons, and other movement disorders |
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Catecholomine hypothesis
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Depression is caused by low levels of serotonin
SO, TCA's block reuptake of norepinephrine, serotionin and/or domanine at nerve synapses so it stays in the system |
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Schizo vs Depression re: Serotonin
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Schizo: Too much serotonin
Depression: Not enough serotonin |
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Tofranil
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Imipramine
Treats enuresis TCA |
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Anafranil
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Clormipramine
TCA Treats OCD |
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Amitryptyline and Doxepin
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TCAs
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SEs of TCAs
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Anticholinergic SEs
Cardiotoxic - tachycardia, palpitation, hypertension, cardiac arrythmia Anticholinergic SEs Confusion, drowsiness, wight gain, fine tremor |
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SSRIs
Selective Serotonin Reuptake Inhibitors 1. What are they 2. What do they treat 3. Why are they better than TCAs (3 reasons) |
1. New antidepressants
2. Treat melancholic depression 3. Less cardiotoxic Less likely for cognitive impairment More rapid onset |
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SEs of SSRIs
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Gastrointestinal problmes (Nausea and constipation/diahrrea) insomnia, dizziness and tremor
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Other uses for SSRIs (4)
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OCD, Bulimia, PTSD and Panic Disorder
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Prozac
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Fluoxetine
SSRI |
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Paxil
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Paroxetine
SSRI |
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Zoloft
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Sertraline
SSRI |
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MAOIs
Monomine Oxidase Inhibitors 1. When used 2. What does it treat 3. How |
1. Only used when no response to a TCA or an SSRI
2. Treats atypical depression symptoms (anxiety, hypersomnia) 3. Inhibits the enzyme that helps block dopamine, norepinephrine and serotonin |
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SEs of MAOIs
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Anticholinergic SEs
Insomnia, agitation, confusion, weight gain, tremor, rash, hypertensive crisis |
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Hypertensive crisis
1. What is it 2. What causes it |
1. SE of MAOIs
2. Can occur if MAOIs are taken with barbituates, antihistamines, amphetamines or foods with the amino acid tyramine (aged cheese and meats, bananas) |
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Isocarboxadid
Phenelzine Tranylcypromine |
MAOIs
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Buproprion
1. Neuros 2. What is it 3. What does it treat (2 things) |
Wellbutrin
1. NDRI (Norepinephrine Dopamine Reuptake Inhibitor) 2. New antidepressant 3. Treats major depresion and the depressive phase of bipolar Treats people who don't respond well to other antidepressants |
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Zyban
1 What is it 2 Neuros |
Wellbutrin's name when used for smoking cessation
NDRI (Norepinephrine Dopamine Reuptake Inhibitor) |
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Venlafazine
1. What is it 2. Neuros 3 What does it treat (3) 4. Benefits |
1. Effexor -New antidepressant
2. SNRI (Selective Norepinephrine Reuptake Inhibitor) 3. Depression, OCD and GAD 4. Faster onset, less dangerous re SEs |
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New antidepressants
1. What do they treat 2. Benefits (3) |
Treats Maj Dep and depressive phase of bipolar
Fewer anticholinergic SEs Less cardiotoxic than TCA's re: overdose No sexual dysfunctions |
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Venlazaxine SE
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Increases blood pressure- need frequent heart monitoring
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Nefazodone - what is it?
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Serzone
SARI Serotonin-2 antagonists/Reuptake Inhibitors |
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Nefazodone SEs
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(Serzone)
Dry mouth, nausea, dizziness, vision problems and confusion |
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Trazodone
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Desyrel
SARI Serotonin-2 antagonists/Reuptake Inhibitors |
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Trazodone SEs
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Sedation, dizziness, nausea, headache
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Lithium
1. What does it do? 2. How |
1. Reduces manic symptoms and mood swings of Bipolar
2. Reuptakes serotonin and norepinephrine |
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Lithium Toxicity
1. Symptoms 2. How to prevent |
Major danger when dose is too high
Diarrhea, nausea, slurred speech, sedation, loss of coordination, fine hand tremor, seizures, coma and death 2. Monitor serum levels |
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Anticonvulsant drugs that act as mood stabilizers
1. When would you use it 2. Who does it treat 3. Who is it better for |
1. Affects serotonin levels
2. Treats people who don't respond to lithium 3. Better than lithium for rapid cyclers and Dysphoric Mania |
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Carbamazapine SEs
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Dizziness, ataxia, visual disturbances, anorexia, nausea and rash
Tolerance develops quickly Blood monotoring required |
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Valproic acid
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Depakote
Anticonvulsant drug that is a mood stabilizer |
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Conazepam
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Klonipin
Anticonvulsant drug that is a mood stabilizer |
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Carbamazapine
1. What is it 2. Who is it best for (2) 3. How does it work? |
Tegretol
Anticonvulsant drug that is a mood stabilizer 2. Best for rapid cyclers and people with dysphoric mania 3. Affects serotonin levels |
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Barbituates
1.How do they work? 2. Problems |
1.Interrupt impulses to the RAS (reticular activating system)
2.Rarely prescribed because of lethal effects Withrawal symptoms can be life threatening Frequently involved in suicides and accidental deaths |
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Amorbarbital
Pentobarbital Secobarbital Pentobarbital |
Barbituates
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Benzodiazepines
1. What's it used for (6) 2. How does it work? |
Most widely used psychatric medication
1.Useful for anxiety, sleep disturbances, seizures, cerebral palsy, alcohol withdrawal, and disorders involving muscle spasms 2. Stimulates GABA |
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Benzodiazepines: Most common SEs
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Drowsiness, slurred speech, ataxia
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1.Alprazolam
2.Oxazepam 3.Triazolam 4.Chordiazepoxide 5.Diazepam |
Benzos
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Lorazepam
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Ativan
Benzo |
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Azapirone
1. What is it? 2. What makes it different (3) |
1. Anxiolytic
2. No sedation Not addictive Not immediately effective - takes several weeks |
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Beta Blocker
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Propanolol (Inderal)
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Beta Blocker Treats (5)
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High blood pressure, Cardiovascular disorders, migraines, glaucoma, physical symptoms of anxiety (sweating, tremor, etc)
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How Beta Blockers work
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Block adrenergic receptors that respond to epinephrine and norepiniphrine - diminishes the exitatory response of epenephrine and norepinephrine
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1. Propanolol SE
2. When lethal? 3. Stopping abruptly? |
(Beta blocker)
1. Bradycardia, shortness of breath, nausea, depression and dizziness 2.Lethal for people with respiratory problems 3. Stopping abruptly causes sweating, headache and cardiac arrythmias |
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Narcotic-Analgesics
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Opioids
Used to treat diahrrea and coughs |
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What opioids do
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Short lived "rush" of euphoric feelings followed by
tranquility, drowsiness, apathy, decreased activity and impaired attention and momory |
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Atypical antipsychotics and motor symptoms
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Alleviates motor symptoms of Huntingtons and Parkinsons
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Dopamine hypothesis
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Schozo is caused by overactivity of dopampine receptors. SO
Traditional antipsychotics block them |
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Opioid tolerance and withdrawal
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Users become dependent to avoid withdrawal symptoms
Flu symptoms Nausea, cramps, fever, joint pain, insomnia |
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Methadone
1. What's it do 2. Addiction/withdrawal 3. How taken |
1. Opioid used for herioin detox
2. Nearly as addictive but withdrawal symptoms milder 3. Can be taken orally to avoid syringe heroin use |
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Amphetamines
1. What is it? 2. How does it work? |
1. Psychostimulant used for narcolepsy and ADHD
2. Release norepinephrine and dopamine THEN block their reuptake |
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Methylphenidate
1. Treats 2. Neuro |
1. Treats ADHD in children and adults
2. Release norepinephren and dopamine THEN block their reuptake |
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1. Amphetamine SEs
2. Prolonged use |
1. Restlessness, insomnia, poor appetite, tremor, palpitations and cardiac arrhythmia.
2. Prolonged use can lead to a psychotic state that looks like Paranoid schizo |
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Methylphenidate SEs
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(Ritalin)
Dysphoria, euphoria, irritability, anxiety, decreased appetite, insomnia |
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Drug Holidays
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Used to prevent growh suprression associated with Ritalin
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Resperidone
1. How does it work 2. SEs |
1. Act on D4 and other dopamine receptors
2. Anticholinergic SEs Agranolcytosis - need careful blood monitoring NMS |
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Fluphenazine
1. What is it 2. How does it work |
1. Traditional antipsychotic
2. Blocks dopamine receptors (especially D2 receptors) |
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Fluphenazine
3. Side Effects |
Anticholinergic SEs
EPS, especially TD NMS |
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EPS examples
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Extrapyramidal SEs
Parkinsonism, akathisis, acute dystonia (muscle spansms in mouth, face and neck) |
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Atypical antipsychotics
4. Problem 5. SEs |
4. Slower onset than traditional
5. NMS, Anticholinergice effects, lowered seizure threshold, sedation Agranulocytosis - careful blood monitoring |
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TCA overdose
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Lethal - small quantities for suicidal clients
Ataxia, impaired concentration, agitation, fever, arrythmia, delirium, seizures and coma |
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Fluoxetine
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Prozac
SSRI |
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Imipramine
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TCA
Treats enuresis |
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Clomipramine
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TCA
OCD |
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Wellbutrin
1. What is it 2. How does it work? |
1. Buproprion - Newer antidepressant
2. Norepineptrine Dopamine Reuptake Inhibitor (NDRI) |
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Zyban
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The name Wellbutrin is called when it is used for smoking cessation
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Effexor
1. What is it 2. How does it work? |
1. Newer antidepressant
2. SNRI - Serotonin, Norepinephirne Reuptake Inhibitor |
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Effexor
3. Uses 4. Benefits (2) 5. SE |
3. Depression, OCD and GAD
4. Less dangerous than TCAs, faster onset 5. May increase blood pressure |
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Nefazodone
1. What is it 2. What does it treat 3. SEs |
1.Serzone - neweer antidepresant
Serotonin-2 antagonists/reuptake inhibitors 2.Treat the depressive phase of Bipolar 3.Sleepiness, dry mouth, nausea, dizziness, blurred vision and confusion |
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Trazodone
1. What is it 2. What does it treat 3. SEs |
1.Serotonin-2 antagonists/reuptake inhibitors
2. Newer antidepressant that also treats Bipolar depressive phase 3. Sedation, dizziness, nausea and headache |
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Buproprion
1. What is it 2. Benefits (4) 3. Problems (2) |
1.Newer antidepressant - Wellbutrin
2. Fewer anticholinergic SEs than TCAs, Less cardiotoxic than TCAs, No sexual dysfunction, Good for people who don't respond to other antidepresssants 3. May aggravate preexisting psychosis and seizures |
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Lithium SEs
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Fine hand tremor, nausea, polyuria and polydipsia
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Depakote
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Valproic acid
Anticonvulsant for Bipolar |
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Klonopin
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Clonazepam
Anticonvulsant for Bipolar |
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Tegretol
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Carbamazepine
Anticonvulsant for Bipolar |
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Sedatives-Hypnotics (3)
1. They are dose dependent, which means (low doses, moderate and high) |
Barbiturates, anxiolytics and alcohol
Low doses - reduce arousal and motor activity Moderate doses - Sedation and sleep High doses - anasthesia, coma and death |
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Sedative-Hypnotic Withdrawal
1. When does it happen 2. What happens 3. Extreme effects |
1. Happens with abrupt cessation
2. Tremors, anxiety, nausea, vomiting, paranoia 3. hallucinations, delirium and deadly seizures |
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Cross tolerance
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Happens with Sed-Hyps
When you become tolerant to one, you can easily develop tolerance for the others |
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Valium
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Diazepam
Benzo |
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Xanax
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Alprazolam
Benzo |
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Serax
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Oxazepam
Benzo |
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Ativan
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Lorazepam
Benzo |
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Librium
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Chlrodiazepoxide
Benzo |
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Benzos-problem
|
Relaxed feeling can lead to psychological AND physical dependence
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Benzo withdrawal
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1. Severe withdrawal symptoms
2. Rebound hyperexitability happens with abrupt cessation - seizures, depersonalization, panic and stroke |
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Propanolol (Inderal)
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Beta blocker
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Percodan
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Opioid
Narcotic-Analgesic |
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Dilaudid
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Opioid
Narcotic-Analgesic |
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Heroin
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Opioid
Narcotic-Analgesic |
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Codeine
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Opioid
Narcotic-Analgesic |
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Demerol
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Opioid
Narcotic-Analgesic |
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Opioid
1. SEs 2. Toxicity |
Decreased visual acuity, increased perspiratino, constipation nausea and vomiting
2. Shallow breathing, muscle rigidity, catalepsy, decreased BP, convulsions and death |
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Methylphenidates contraindicated for people with (6)
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Anxiety
Anorexia Severe hypertension Functional psychosis Drug/Alcohol abuse Tourettes/motor tics |