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16 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Leflunomide |
Inhibits dihydoorotate dehydrogenase (dis pyrimidine synthesis) |
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Methotrexate, trimethoprim and pyrimethamine |
Inhibits dihydrofolate dehydrogenase (dis pyrimidine synthesis) (dec dTMP deoxythymidine monophosphate) |
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5-fluorouracil |
Inhibits thymidine synthase (dec dTMP) dis pyrimidine synthesis |
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6-mercaptopurine (6-mp) |
Prodrug azathioprine. Inhibit denovo purine synthesis. |
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Mycophenolate and ribavarin |
Inhibit inosine monophosphate dehydrogenase (purine synthesis) |
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Hydroxyurea |
Inhibits ribonucleotide (dec pur+pyr) |
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GAG: GLYCINE, ASPARTATE, GLUTAMINE |
Necessary for purine synthesis |
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Adenosine Deaminase Deficiency |
toxicity in lymphocytes, inc deoxyadenosine |
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Lesch Nyhan Syndrome |
X-Recessive, disability, self mutilation, aggression, hyperuricaemia, orange sodium urate crystals in diaper, gout, dystonia |
HGPRT absent so Hyperuricaemia, Gout, Pissed Off, Retardation, dysTonia |
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Methionine and Tryptophan |
AUG and UGG codons |
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Floroquinolones |
Inhibit prokaryotic topoisomerase II (DNA gyrase) and topo IV |
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Etoposide, teniposide |
Eukaryote topoisomerase II |
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Missense mutation |
Sickle cell anaemia (glu subs with val) |
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Frameshift |
Duchene Muscular Dystrophy, Tay Sachs disease |
Not divisible by 3 |
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Splice Site |
Rare cause of cancers, dementia, epilepsy, some beta thalassemia |
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Shock proteins |
Facilitate and maintain protein folding |
Yeast shock proteins in yeast |
