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59 Cards in this Set

  • Front
  • Back
Thermoregulation response to cold (7)
1)incr heat production
2)decr heat loss
3)incr muscle tone
4)skin vasoconstriction
5)incr voluntary exercise
6)behavior adap (warm clothes)
7)nonshivering thermogenesis (E and thyroid hormone)
Thermoregulation response to heat (7)
1)decr heat production
2)incr heat loss
3)decr muscle tone
4)skin vasodilation
5)decr voluntary exercise
6)sweating
7)behavior adap (cool clothes)
Alterations in thermoregulation for...
a)fever
b)hyperthermia (2)
a)incr set pt
b1)incr heat production
b2)decr heat dissipation
Etiology of fever (4) and which is main cause
1)infexn***
2)inflammation
3)drugs
4)neoplasm (especially ones of hypothalamus)
Clinical course/symptoms of fever (besides high temp) (5) (and which 2 are first 2 symptoms in kids)
1)chills/flushing b/c normal body temp is too low for new set pt
2)pallor (loss of color)
3)irritability***
4)anorexia***
5)malaise (not feeling well)
Oral thermometer (2)
a)best in adults/kids over 3
b)must be placed in SL pocket
Rectal thermometer (2)
a)BEST FOR NEONATES (3 months or younger)
b)average temp is 1F higher than oral method
Tympanic thermometer (2)
1)best for children 4months to 3yo
2)variable readings
What to consider before taking a temperature (2)
1)oral intake prior to measurement
2)local inflammation @ site of measurement
What to get before assessing fever (6)
1)medication history
2)medical history (mainly liver/renal disease)
3)social history
4)drug allergies
5)physical exam
6)labs/cultures
Physiologic variables to fever (4)
1)age (older = decr body temp)
2)gender (F higher temp than M)
3)sleep-wake cycle
4)local climate
APAP and fever
a)dosing for kids/adults
Kids- 10mg/kg q6h, max 65mg/kg/d

Adults- 325-500mg q4-6h max of 4000mg/day (lower doses for renal/hepatic insufficiency)
NSAID and fever
a)kid dosing
b)adult dosing (2)
a)5-10mg/kg q6-8h, max 40mg/kg/d
b)200-400mg q4-6h; max 3200mg daily; lower dose in renal/hepatic insufficiency
ASA precautions (3)
1)avoid in kids UNDER 16 (reye's/encephalopathy)
2)asthma or bleeding disorders
3)pregnancy
Hydration to control fever
a)necessary to...
b)OTC products for kids/adults
a)maintain blood flow and intravascular volume
b)adults (gatorade, carbonate beverage)
kids (pedialyte)
Physical methods to control a fever (4) and thing about them
NOT RECOMMENDED
1)sponging
2)ice packs
3)cooling blankets
4)circulating fans
Fever complication
FEBRILE SEIZURES (tonic seizure)
Febrile seizure stuff (6)
a)occurs within first 24hrs
b)in 2-4% of children
c)in kids 6months to 5yo
d)in fevers 102F plus
e)associated w/ degree and rate of rise of fever
f)having 1 will incr risk of having another
Febrile seizure treatment and thing about them (3)
TREAT BUT WON'T PREVENT
a)antipyretics
b)diazepam
c)anticonvulsants
Fever conditions requiring immediate evaluate (8)
1)2months or younger
2)6months to 24months w/ rectal temp greater than 102
3)immunocompromised
4)temp over 106 in adults
5)asplenia
6)pregnancy
7)cardiac disease
8)epilepsy
Hyperthermia def (3)
1)normal set pt temp
2)imbalance b/w heat gain/loss
3)pt can't get rid of heat and is producing too much
Hyperthermia management (2)
1)medical emergency
2)seek immediate medical attn
Barriers to pain control (3)
1)inadequate knowledge of HC professionals
2)cultural/social barriers
3)gov't regulations
Inadequate knowledge of HC professionals consists of...(5)
1)MD reluctance to prescribe opioids
2)lack of knowledge on equianalgesic dosing
3)poor pain assessment
4)misunderstanding of ADR's and addiction
5)"ceiling effect"
First line and second line treatment for nociceptive pain
1st- opioids
2nd- adjuvant/coanalgesics often req'd
Neuropathic pain
a)underlying cause
b)desc
c)can be caused by...(4)
a)results from damage to central or peripheral nervous system
b)burning, stabbing, shooting pain
c)compression, infiltration, ischemia, metabolic injury
First and second line treatment for neuropathic pain
1st- adjuvants/coanalgesic often reqd
2nd- opioids
Acute pain
a)desc (2)
b)ex cause (2)
c)DPh role...
a1)well defined pattern
a2)objective physical signs (sweat, BP, pulse)
b)dental pain, traumatic injury
c)conforting
Chronic pain
a)def
b)desc.
c)DPh role
a)persistent pain greater than 3 months w/o a well defined onset
b)lacks objective signs due to adaptations, no test for it
c)frustrating and improve fxnality
Pain history mechanism
PQRST
P- provocation/pallation (what makes worse/better)
Q- quality of pain
R- region and radiation
S- severity on 0-10 scale
T- timing (sudden/gradual/length)
One dimensional pain measurement tools (2)
1)visual analogue scale (line w/ no pain and worst pain at ends)
2)numerical rating scale
WHO three step analgesic ladder (3)
1)mild pain (non-opioid + adjuvant) (NSAIDS)
2)moderate pain (opioid + nonopioid + adjuvant) (opioid w/ APAP and tramadol)
3)severe pain (opioid + nonopioid + adjuvant) (opioid not in combo w/ APAP so no limits on dosing)
Adjuvant?
gabapentin
Pain adjuvant referral (4)
1)psychiatric
2)rehab/PT
3)pain clinic
4)neurology
General principles of non-opioid analgesia (4)
1)dose agents ATC
2)use max dose of each
3)switch to agents of a different class if one doesn't work
4)all agents have ceiling effect
Ceiling effect
if above max dose all you do is increase SE's
Tylenol
a)pain dosing
b)SE's (3)
a)325-650mg q4-6h (oral or rectal)
b)rash, hepatotoxic, incr risk of liver disease
2 NSAIDS w/ no anti-platelet effects
1)salsalate
2)choline magnesium salicylate
NSAIDS
a)....b/w analgesics
b)really good for...
c)only injectable one
a)equal analgesia b/w all agents, @ max doses, of this class
b)BONE PAIN
c)toradol
COX2 vs. nonselective NSAID (2)
a)decr GI effects
b)decr renal effects
ASA max dose
4000mg/day
Naproxen max dose
1500mg/day
All OTC NSAIDS are of ____ category
Proprionic Acids
GI toxicity of NSAIDs and how to prevent
cause duodenal AND gastric ulcers use PPI not H2 to protect against them (or use misoprostel (cytotec))
COX2
a)affect on anti-plaletes
b)good for...
c)may cause...
a)no effect on platelets
b)pts w/ risk factors for GI ulcers/bleeding
c)CV events
ASA effect on platelets
permanently acetylates COX1&2
NSAIDs interact w/...(2)
1)warfarin
2)antihypertensives
a)Renal sparing NSAID
b)GI/platelet sparing NSAID
c)NSAID w/ worst GI effects
a)Sulindac
b)COX2's
c)Prioxicam
Worst tolerated NSAIDS (one other thing about this drug) and best tolerated
Indomethacin is worst (incr CNS toxicity in old)

ASA/Ibu best tolerated
General principles of opioid use (9)
1)choose the appropriate route
2)start w/ lowest dose possible
3)titrate quickly
4)schedule agents ATC
5)use PRN doses for breakthru
6)use equianalgesic doses
7)anticipate and manage ADR's
8)use as much drug as necessary
9)understand tolerance and dependence vs. addiction
Morphine
a)dosing
b)drug of choice for...
c)dosage form
d)metabolism
e)ratio?
a)use LA ATC and SA for breakthru
b)chronic severe pain
c)all of em
d)significant first pass
e)Oral to IV; 3:1
Fentanyl
a)onset
b)duration
c)dosing
d)ORAL MORPHINE conversion
a)24hrs b4 onset of analgesia
b)48-72hrs
c)Max 25mcg/hr starting dose
d)oral morphine dose for 24hrs divided by 2 (in mcg/hr)
Pts acceptable to get fentanyl (3)
1)pts w/ intractable n/v
2)pts w/ chronic, stable baseline pain!!!!
3)NOT FOR ACUTE, UNSTABLE PAIN
No tolerance develops to what opioid SE? and how to treat?
CONSTIPATION

senokot 2 hs and docusate 100mg bid
How to calc a PRN dose?
15% of daily dose every 3-4h
Antidepressant as adjuvants
a)which ones for what
b)how to dose
c)ADR's (5)
a)TCA's good for neuropathic pain
b)start low and gradually incr
c)orthostasis, sedation, constipation, anti-SLUD, confusion
Anticonvulsants as adjuvants
a)which ones for what? (5)
b)ADR's (4)
a)gabapentin, pregabalin, tegretol, phenytoin, valproic acid for neuropathic pain
b)sedation, confusion, GI, bone marrow suppression
Neuropathic pain
a)Poor response to...
b)Gabapentin dosing
c)Amitriptylline dosing
a)NSAIDs/opioids
b)100mg TID
c)10-25mg q hs
For bone pain use...
NSAIDs