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15 Cards in this Set
- Front
- Back
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What is SLE? |
Production of antibodies against nucleic acids, erythrocytes, coagulation proteins, phospholipids, lymphocytes, platelets, etc |
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What is the most characteristic autoantibodies produced in SLE against? |
Nucleic acids and other DNA material |
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Who is SLE most common in? |
20-40yo, blacks > whites |
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What is the triad of symptoms? |
Fever, joint pain (asymmetrical), facial rash in women of childbearing age |
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What are other common clinical findings in SLE? |
Facial rash Photosensitivity Oral/NP ulcers Renal/neuro disease Hematological disorders Cardiovascular disease (pericarditis) |
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How is SLE diagnosed? |
ANA, CRP, complement levels, x-ray, ECG, lumbar puncture, renal biopsy, and skin biopsy |
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How is SLE treated? |
NSAIDs, antimalarial (hydroxychloroquine), corticosteroids, immunosuppressive drugs (methotrexate, azathioprine), IVIG is temporary |
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ABO are _______ Universal donor: ___ Universal acceptor: _____ |
ABO are antigens Universal donor: O Universal acceptor: AB |
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What does the RhD protein tell you? |
tells you if the person is positive or negative patients who express the D antigen on the RhD protein are Rh-positive (dominant "D") patients who do not express the d antigen on the RhD protein are Rh-negative (lowercase "d") |
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What genotypes will an Rh positive person have? Rh negative? |
Rh positive - DD or Dd since D is dominant Rh negative - dd |
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What immune response will occur with an Rh negative mother and an Rh positive baby? |
Hemolytic anemia |
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Primary vs secondary immune deficiencies |
Primary - congenital Secondary - acquired (by another illness i.e. cancer, aging, virus) *more common* |
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What are the 5 groups of primary immunodeficiencies? |
B-cell deficiencies T-cell deficiencies (affects B cells thus lacks antibodies) Combined B and T cell deficiencies Complement deficiencies Phagocytic deficiencies |
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What is DiGeorge syndrome? |
Partial or complete absence of T-cell immunity |
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