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13 Cards in this Set
- Front
- Back
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Phenytoin 1
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Blockade of high frequency neuronal firing (use dependant Na channel inactivation)
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Phenobarbitone 2
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Enhance GABA A Cl ion conductance
Some Na channel activation |
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Clonazepam
Clobazam Diazepam Lorazepam 1 |
Enhancement of GABA A Cl ion conductance
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Carbamazepine 2
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Blockade of high neuronal frequency (Use dependant Na channel inactivation)
Minor Ca channel antagonist |
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Oxcarbazepine 2
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Blockade of high frequency neuronal firing (use dependent Na channel inactivation)
MHD is the active metabolic of Oxcarb and adjoins for the anti-seizure activity |
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Valproate 3
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Blockade of high frequency neuronal firing (use dependant Na channel inactivation)
Reduction in low threshold Ca currents (T currents) in thalamic neurons Stimulates GABA synthesis and inhibits GABA inhibition |
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Ethosuxamide 1
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Reduction in low threshold Ca currents (T currents) in thalamic neurons
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Lamotrigine 2
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Blockade of high frequency neuronal firing (use dependant Na channel inactivation)
Reduction in glutamate release |
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Gabapentin 1
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Block voltage gated presynaptic N,P/Q Ca channels by binding to the alpha2delta subunit
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Pregabalin 1
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Block voltage gated presynaptic N,P/Q Ca channels by binding to the alpha2delta subunit
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Levetiracetam 1
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Binds to SV2A protein on synaptic Nt vehicles and inhibits Nt release
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Topiramate 3
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Blockade of high frequency neuronal firing (use dependant Na channel inactivation)
Enhanced GABA activity Blockade of AMPA type glutamate receptors |
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Vigabatrin 1
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Irreversible inhibition of GABA transaminase (reduces breakdown of GABA)
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