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21 Cards in this Set
- Front
- Back
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Beta-Lactam |
Target PBP and prevent wall cross linking |
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Glycopeptides |
Bind and occupy D-Alanine to prevent cross- linking |
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Daptomycin |
Lipid portioninsert into baterial membrane ---> form ion-conducting channel ----> Cell death |
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Colistin |
(+) charge binds to (–) charge liposaccharide on outermembrane ----> displace Ca2+ and Mg2+ ---> destabilizemembrane |
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Rifamycins |
Bindsto RNA polymerase ---> blockmRNA elongation |
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Aminoglycosides |
Binds to 30S ---> causing mis-match of tRNA |
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Macrolides and Ketolides |
The macrolides bind reversibly to the 50S subunit ----> inhibit peptidyltransferase ----> prevent formingpeptide bonds between the amino acids. |
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Tetracyclines and Glycylcyclines |
lBinds to 30S à prevent tRNA binding ----> block protein synthesis |
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Choramphenicol |
Binds to 50S ---> blockformation of peptide bond |
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Clindamycin |
Binds to 50s ---> inhibitprotein synthesis |
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Streptogramins |
Binds to 50S ---> preventprotein synthesis |
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Linezolid |
Binds to 50S ---> prevent assiociation with 30S ----> ribosome can’t form |
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Nitrofurantoin |
poorly understood – inhibit translation |
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Sulfa Drugs |
Competitively Inhibit DHT --->> Prevent production of Folic acid--->> No DNA replication |
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Quinolones |
Target Topoisomerase(G+) and DNA Gyrase(G-) |
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Metronidazole |
must be reduced to be active – forms free radicals (i.e. super oxide) ----> DNA breakage
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Bacitracin |
Inhibitssynthesis of bacterial cell wall (Via DNA?) |
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Mupirocin |
–Reversiblyinhibits Aminoacyl-tRNA synthetase ---> Prevents AA attaching to tRNA (i.e. prevent “loading” or“charging”) ---> stop protein synthesis |
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Isoniazid |
Inhibit mycolic acid synthesis – important component of cell envelope |
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Pyrazinamide |
•MOA: unclear –Targets enzymes for synthesis ofmycolic acid –Reduction of intracellular pH –Disrupt membrane transport |
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Ethambutol |
•Target the synthesis ofmycobacterial cell wall |
