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22 Cards in this Set

  • Front
  • Back
Peptides (encoded by non-MHC genes) derived from donor's polymorphic proteins and brought in on MHC I molecules, inducing a less potent immune response.

Involved in bone marrow transplant & GVHD
Minor H antigen
grafting tissue from one individual of a species to another member of the same species
Allograftic
Grafting tissue from a member of one species to a member of another species
Xenograft
Graft rejection type
1. Hyperacute

2. Acute

3. Chronic
graft rejection that occurs immediately or within days, mediated by Ab and complement
Hyperacute
Graft rejection that occurs within 1-2 weeks, mediated by CTL
Acute
Graft rejection that occurs after months or years, mediated by CD4 DTH
Chronic
For MHCI what alleles show strong reaction in allorecognition?

For MHC II?
HLA-A and HLA-B

HLA-DR
When T cells recognize unprocessed allogenic MHC molecule on graft APCs, stimulates CTL
Direct allorecognition
T cells recognize processed peptide of allogenic MHC bound to self MHC moleule on host APC

stimulates both CD4 & CD8
Indirect allorecognition
To determine tissue matching between donor and recipient
MHC Typing
using different Ab to distinguish between HLA-B, A, and DR alleles

out of date
Serological test
Used to test MHC compatibility between donor and recipient

Mix lymphocytes from host and donor and see how they react
Mixed lymphocyte reaction
Bone marrow transplant is commonly used to treat what kind of patients?
immunocomprised patient including leukemia, lymphoma, and congenital immunodeficiency
A tissue or organ graft in which the donor and the recipient are the same individual
Autologous BMT
An organ or tissue graft from a donor who is the same species but genetically not indentical
Allogenic BMT
primary immune components in mediating tumor timmune response
T cells, NK, macrophages
Which tumor antigen would be normal cellular proteins expressed abnormally
CEA, alpha-FP, PSA, CA-125, Bence Jones
Which tumor antigen would be viral proteins?
E6, E7
Which tumor antigen would be oncogene product?

Mutated cellular protein?
Bcr/Abl, p53

p53
Effectors in tumor immune response
CTL main effector, cross presentation and Th1 cells involved, NK and macrophages contribute
Tumor antigen is
a tumor suppressor mutant