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22 Cards in this Set
- Front
- Back
Peptides (encoded by non-MHC genes) derived from donor's polymorphic proteins and brought in on MHC I molecules, inducing a less potent immune response.
Involved in bone marrow transplant & GVHD |
Minor H antigen
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grafting tissue from one individual of a species to another member of the same species
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Allograftic
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Grafting tissue from a member of one species to a member of another species
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Xenograft
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Graft rejection type
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1. Hyperacute
2. Acute 3. Chronic |
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graft rejection that occurs immediately or within days, mediated by Ab and complement
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Hyperacute
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Graft rejection that occurs within 1-2 weeks, mediated by CTL
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Acute
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Graft rejection that occurs after months or years, mediated by CD4 DTH
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Chronic
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For MHCI what alleles show strong reaction in allorecognition?
For MHC II? |
HLA-A and HLA-B
HLA-DR |
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When T cells recognize unprocessed allogenic MHC molecule on graft APCs, stimulates CTL
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Direct allorecognition
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T cells recognize processed peptide of allogenic MHC bound to self MHC moleule on host APC
stimulates both CD4 & CD8 |
Indirect allorecognition
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To determine tissue matching between donor and recipient
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MHC Typing
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using different Ab to distinguish between HLA-B, A, and DR alleles
out of date |
Serological test
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Used to test MHC compatibility between donor and recipient
Mix lymphocytes from host and donor and see how they react |
Mixed lymphocyte reaction
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Bone marrow transplant is commonly used to treat what kind of patients?
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immunocomprised patient including leukemia, lymphoma, and congenital immunodeficiency
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A tissue or organ graft in which the donor and the recipient are the same individual
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Autologous BMT
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An organ or tissue graft from a donor who is the same species but genetically not indentical
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Allogenic BMT
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primary immune components in mediating tumor timmune response
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T cells, NK, macrophages
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Which tumor antigen would be normal cellular proteins expressed abnormally
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CEA, alpha-FP, PSA, CA-125, Bence Jones
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Which tumor antigen would be viral proteins?
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E6, E7
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Which tumor antigen would be oncogene product?
Mutated cellular protein? |
Bcr/Abl, p53
p53 |
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Effectors in tumor immune response
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CTL main effector, cross presentation and Th1 cells involved, NK and macrophages contribute
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Tumor antigen is
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a tumor suppressor mutant
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