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15 Cards in this Set
- Front
- Back
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Phases of Type I
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Sensitization: Ag exposure-IgE binds to FceR on mast cell
Eliciation: re-exposure of Ag cross-links IgE on mast cell Late phase reaction: mast cells release cytokine causing inflammation and tissue damage |
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Type II: blood transfusion reaction
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During transfusion of non-matching type of blood, these IgMs bind to incoming blood and activate complement to induce cell lysis
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Localized inflammation caused by deposition of immune complexes
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Type III: Arthus reaction
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Systemic inflammation to immune complexes deposited in many areas of the body
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Type III: Serum Sickness
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Examples of Type IV
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Contact dermatitis, tuberculin test, granulomatous
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A DTH targeted to skin, eczema occurs at antigen-contact site
ex: poison ivy, latex, metal |
Type IV: Contact dermatitis/sensitivity
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Cutaneous inflammatory reaction, firm red swelling of skin peaked after antigen exposure
ex: TB test |
Type IV: Tuberculin-Type
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Continuous accumulation of macrophages leads to clusters of epithelioid cells that fuse to form giant cells caused by inability of macrophages to degrade phagocytozed bacteria
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Type IV: Granulomatous
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What type of hypersensitivity does not involve antibody?
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Type IV hypersensitivity is mediated by T cells.
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Allergens coming from which two routes would have anaphylaxis outcome?
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Food ingestion & blood
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PK test
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Test for presence of immediate hypersensitivity
Test serum from atopic individual and inject into normal person. |
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RAST
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Using person's blood sample & radiolabeling, detects the amount of IgE that reacts with suspected/known allergen
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Cycopenia or anemia is what type of hypersensitivity?
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Type II hypersensitivity
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Difference between Type II and III hypersensitivity?
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Type II is mediated by Abs IgM, IgG. (Ab binds to auto-antigen)
Type III is mediated by antigen-Ab immune complex (Ab binds to foreign antigen) |
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TB test and PPD, mantoux test
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TB test: tuberculin is a lipoprotein isolated from M.tunerculosis and is used to detect previous exposure
PPD, mantoux test is a purified protein derivative that takes the place of the TB test. |
