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12 Cards in this Set
- Front
- Back
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What is the difference btween the 2 enterobacteriaceae (shigella and salmonella) in regards to ferment/production
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Shigella: does not ferment lactose, and does not produce H2S
Salmonella: does not ferment lactose but DOES produce H2S |
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What is the MOA for salmonella?
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1. Triggers own endocytosis
2. Ingested by macrophages 3. Modify phagosome into spacious phagosome (unlike shigella which escapes into cytoplasm). |
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What diseases are caused by salmonella typhi?
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Food poisoning: salmonellosis (gastroenteritis)
Typhoid fever: enteric fever Think Salmon is colon |
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Know differences btw the S. typhi and S. enteritis
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See paper
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-Traveler's disease
-Heat labile toxin to allow adherence -Heat stable toxin: inc. cGMP, hypersecretion of water -All are plasmid encoded on mobile-genetic elements -Watery, cholera-like diarrhea, rice-colored |
ETEC: enterotoxigenic E.coli
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No toxins, diarrhea like shigella
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EIEC: enteroinvasive E. coli
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Bundle forming pilli (type IV)
Tir: modified inside, inserts on epi Intimins: proteins that interact with Tir on receptor forming attachement, formation of pedestal LEE locus, pathogenicity island |
EPEC: Enteropathhogenic E. Coli
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LEE locus, intimin, Tir
Encoded by bacteriophage Does not ferment sorbitol, way to differentiate from other E.coli |
EHEC: enterohemorrhagic E. coli
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found in undercooked/contaminated meat
Hemorrhagic colitis: very bloody watery diarrhea |
EHEC
0157: H7 |
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No antibiotics needed. If use, can cause lysogenic phage to activate inc. shiga-like toxin
Cure is hydration |
EHEC
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Causes UTIs
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UPEC
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Founds in newborns causing neonatal sepsis, meningitis, septicemia
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SEC
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