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189 Cards in this Set

  • Front
  • Back
What drug do you use to prepare patients with pheo for adrenalectomy?
alpha blockers such as prazosin, daxazosin, and terazosin
What happens to macroprolactinomas during pregnancy?
they enlarge
Name the "3Ps" of MEN1
pituitary adenoma
hyperparathyroidism
pancreatic islet cell disease
Name the 2 best tests for screening for Cushing's Syndrome?
24-hr urine free cortisol excretion
the 1-mg overnight dexamethasone suppression test
How do you manage a patient who has osteoporosis and is getting worse in spite of bisphosphonate therapy (and has adequte vit D and calcium intake)
change to PTH agonist teriparatide
What would you worry about in a patient with symptoms of central DI and a thickened pituitary stalk?
infiltrative diseases such as sarcoid or Langerhan Cell Histiocytosis
Name the disease:
mental status changes
hypothermia
hyponatremia
hypoventilation
myxedema coma
Initial Management of Myxedema Coma
IV levothyroxine
hydrocortisone
broad spectrum antibiotics
What happens to the PSA when you give testosterone to a man with hypogonadism?
It doubles then stabilizes after 6 months. Any greater increase should prompt an eval for prostate CA
What are the FSH and LH like in hypogonadism?
low
In a patient with hyperthyroidism and an inappropriately normal TSH, what do you suspect?
a pituitary cause
Initial management of hypercalcemia?
IV hydration. No furosemide indicated anymore.
In which patients should one NOT use pioglitaone?
Heart failure patients - it causes edema and can exacerbate heart failure.
In a patient hospitalized for illness who is found to have elevated fasting glucose, what do you do next?
repeat the tests after they have been discharged and have stabilized.
How do you manage patients with hyperthyroidism and mild eye disease who cannot take methimazole?
radioactive iodine can be used if the eye disease is mild but give prednisone with it
In patient with biochemically proven Cushing's Syndrome who have a negative MRI, what do you do next?
bilateral petrosal sinus catheterization
Do you have to ultrasound someone with Hashimotos?
no
Can you use metformin or sulfonurea's in renal failure patients?
no
Can sitagliptin be used in renal failure patients?
yes.
Name the disease:
subacute migratory polyarthralgia & arthritis
tenosynovitis
pustular/vesicopustular or papular lesion
disseminated gonoccocal infection
Which type of kidney injury is seen after prolonged ischemia?
acute tubular necrosis
What kidney injury should you think about when you see muddy brown casts?
acute tubular necrosis
what type of kidney injury does cisplatin cause?
acute tubular necrosis
What type of kidney injury do IV aminoglycosides cause?
acute tubular necrosis
what type of kidney injury does radiocontrast cause?
acute tubular necrosis
How many days after surgery is it safe to use recombinant tPA in a patient?
14 days (not counting head surgery)
Treatment of pancreative insufficiency
enzyme replacement
What is the most likely cause of renovascular hypertension in a young person?
fibromuscular dysplasia
How do you diagnose fibromuscular dysplasia (when you suspect a renovascular etiology of HTN in a young person)
intra-arterial digital subtraction angiography
What toxic state do you suspect in someone with an increased osmolar gap in the setting of positive serum and urine ketones and NO metabolic acidosis?
isopropyl alcohol poisoning
What is the imaging modality of choice in patients with complex kidney cysts or mass lesions who have ESRD on HD?
CT with contrast of the abdomen
Can people with SLE have increased levels of RF?
yes
Do people with SLE require DMARDS for joint deformities?
No, these are Jaccoud arthropaties and are reducible. While they mimic those or RA they are usually not erosive.
Management of a mild SLE flare:
hydroxychloroquine
What electrolyte disturbance might hospitalized alcoholic patients experience after resuscitation that causes confusion, rhabdo, hemalytic anemia, severe mm weakness
Hypophosphatemia
What do you use to assess mental status changes in mechanically ventilated ICU patients?
Confusion Assessment Method for ICU
Treatment of migraines in breastfeeding mothers
sumatriptan or frovatriptan
What is the most common cause of central adrenal insufficiency?
Use of exogenous corticosteroids
How can you prevent symptoms of allergic rhinitis when someone has a known allergen?
intranasal cromolyn sodium taken prior to exposure to allergen
What is the appropriate management of someone who has abnormal LFTs and increased ferritin?
screen them for HFE gene for hemochromatosis so family members can be screened?
What is the appropriate next step in patients with metabolic syndrome and persistantly elevated LFTs
liver biopsy
What is a possible consequence of the bowel prep agent sodium phosphate?
acute phosphate nephropathy --> AKI and increased phos
What disorder can cause recurrent serious infections in patients with CLL?
Hypogammagloinemia
Treatment of acute bacterial pneumonia and a parapneumonic effusion with septations
immediate pleural space drainage +/- fibrinolytic therapy
When you have very high suspicion for a ventricular arrhythmia in a patient with LV dysfunction should you do an event monitor before placing an ICD?
no
Treatment of CAP that occurs after influenza infection:
vanc and levo (because there is a higher likelihood of staph pneumonia
Treatment of BV
metronidazole for 7 days
Management of a spinal abscess in the setting of neurologic dysfunction < 36 hours
emergent laminectomy
Name the disease: inflammation of the cartilage of the nose, ears, trachea, joints triggered by local trauma
relapsing polychondritis
diagnosis of allergic contact dermatitis
epicutaneous patch testing
Who cannot undergo carotid endarterectomy?
stenosis above the level of C2, radiation-induced stenosis, history of radical neck surgery
In a person who cannot undergo carotid endarterectomy, what is the next best procedure of choice
carotid angioplasty and stenting
When working a man up for hypogonadism, what is the next step when total testosterone is 200-350?
Check a free testosterone level
What is one of the most common causes of obstructive nephropathy in women?
cervical cancer
Treatment of mitral stenosis in pregnancy
beta blockade
Name the disease: dementia characterized by:
dream-enactment
cognitive decline
parkinsonianism
visual hallucinations
Dementia with Lewy Bodies
What is the next step in the work up of someone with asthma who has nocturnal symptoms?
Trial of PPI
What is the most effective method of diagnosis of tachycardia in the outpatient setting?
Continuous loop monitoring (better than 24-hr ambulatory monitoring)
Features suggestive of SVT (3)
termination with valsalva
sustained episodes
specific triggers such as dehydration, caffeine, bending over
Diagnostic test of choice in patients with atypical appearing non healing ulcers
skin biopsy
Goal TSH levels in patients s/p thyroidectomy due to mild thyroid cancer?
0.3-0.6
Name the disease: an insidious onset of myopathy, EMG shows mixed pattern of myopathic and neurogenic changes, moderately elevated CKs, asymmetric physical exam, EM shows vacuoles containing particles resembline myxovirus or paramyxovirus
inclusion body myositis
What is the most imminent danger after SAH?
Re-bleeding
Name the disease: Kussmaul's sign (elevated JVP with inspiration) and an early diastolic sound
Constrictive Pericarditis
Treatment of a patient with PAN and hepatitis B
short term high dose corticosteroids
lamivudine
Name the disease: constitutional symptoms, peripheral neuropathy, rash, skin biopsy showing necrotizing vasculitis, testicular pain
PAN
What disease is see in in 50% of patients with PAN?
Hepatitis B
What is the next step? A patient with persistently elevated CK and proximal mm weakness...
proximal mm MRI to identify if muscle inflammation present and to identify a biopsy site
Evaluation of a solitary pulmonary nodule always begins by:
evaluation of prior imaging studies, if available
Diagnostic Criteria for Bulemia Nervousa
Episodes of binging at least 2x/wk for 3+ mo followed by purging or other compensatory behavior such as exercising.
In a patient with newly diagnosed likely advanced gastric adenocarcinoma, after EGD the next step in staging is:
a CT scan of the abdomen to assess for metastatic disease. H. Pylori testing is done in early stage disease only.
Name the disease: limb weakness & fasciculations, atrophy, brisk deep tendon reflexes, extensor plantar responses, +/- tongue atrophy and fasciculations
ALS
What do you do with a patient with a new TIA in the past 24 hours and a moderate ABCD2 score?
Admit them to the ER/hospital for urgent evaluation because stroke recurrence is highest in the first two days and imaging procedures for identifiable causes can be expidited.
What is unique about the FENa in patients with chronic kidney disease and prerenal azotemia?
It can be > 1%
What cancer is immunostain CK-7 suggestive of?
breast
Women with axillary lymph node mets of adenoCA and unknown primary with immunostain CK-7 should be treated how?
Stage II breast CA with R mastectomy and axillary LN dissection
Management of mild-to-moderate ulcerative proctitis
topical mesalamine
Management of papillary or follicular thyroid cancer:
thyroidectomy followed by radioiodine-131.
What is the work up of a multi-nodular goiter?
Essentially the same as solitary nodules, with size (>1cm) & ultrasound characteristics used as selection for biopsy.
Management of IgA nephropathy:
ACEi or ARB + pulse dose corticosteroids
Name the disease: persistant hematuria and proteinuria, HTN, biopsy shows mesangioproliferative lesions throughout all glomeruli with cellular proliferation
IgA Nephropathy
What disease is most commonly associated with vitiligo?
Autoimmune thyroid disease - should check a TSH in a patient with vitiligo.
What is the best diagnostic test to evaluate oropharyngeal dysphagia?
Videofluoroscopy (i.e. Barium swallow)
How do you tell apart oropharyngeal from esophopharyngeal dysphagia?
In oropharyngeal dysphasia is usually liquids only, cough associated with the swallowing difficulty, and symptoms occur immediately upon initiation of a swallow.
What do you do with an epileptic patient who has been seizure free for several years but whose medication is slightly subtheraputic by lab value?
leave it, go based on side effects and clinical symptoms rather than strict lab values.
Treatment of vaginal trichomonas
one day of metronidazole
Modality to use to help the healing of a diabetic ulcer
contrast casting
BNP levels in obese persons - what's up?
They are lower even in heart failure.
What is the ACTH level like in subclinical cushing's syndrome due to a functioning adrenal incidenteloma?
very low or zero, because the adrenal gland is functioning independent of the pituitary (i.e. ACTH-independent adrenal adenoma). ACTH will be suppressed by the cortisol being inappropriately secreted.
What are the characteristics of an adrenal adenoma that needs to be removed
>6cm (or 4-6)
>20 Hounsfield units
high vascularity
any level of functionality
What is the next step in a patient with angina symptoms and signs of heart failure?
Cardiac Catheterization
How long do you have to bridge to warfarin for new DVT?
5 days at least, with at least two measurements of INR >2
In patients who are too sick for surgery, what is an alternative treatment of achalasia?
botulin toxin injection
Treatment of severe community aquired pneumonia in a PCN-allergic patient.
fluiroquinolone and aztreonam
How do you monitor respiratory status in a patient with tenuous status secondary to neuromuscular weakness disease such as MG?
serial vital capacity (ABGs don't work in these patient's whose CO2 typically goes down)
Treatment of delerium in an elderly ICU patient
haldol
What is the first vent management to treat a patient with ARDS and severe hypoxemia?
increase PEEP
Name two pharmacologic reatments for urge incontinence
oxybutynin or tolterodine
Management of a woman with chronic pelvic pain and completely normal medical work up (inlc imaging)
CBT
What is this: a person using an inhaled corticosteroid or a fluorinated topical steroid on the face gets a pustular and papular rash around his or her mouth
perioral dermatitis
Name the cancer: young never smoker, indolent, endobronchial obstruction
carcinoid tumor
What is the first step in management for a patient who presents with a papillary mm rupture with severe MR and in cardiogenic shock?
Urgent mitral valve repair (will concurrent cath to see if any other areas of ischemia can be reversed.
When a person on a seizure med is not responding, what is the next step?
Taper over to a different seizure med. Monotherapy is preferred over polytherapy. Surgery isn't considered until at least two seizure meds have been tried.
What electrolyte abnormality can be seen in patients treated with pentamadine, amiloride, triampterene and trimethoprim?
Hypokalemia due to impared kidney potassium excretion.
Name the disease: acute inflammatory arthritis of the ankles, erythema nodosum and hilar lymphadenopathy
Lofgren syndrome, a variant of sarcoidosis
What is the imaging procedure you do when a patient presents with abdominal pain radiating to the back and elevated pancreatic enzymes?
ultrasound, to identify gallstones.
What can happen if you have DI treated with desmopressin and drink a lot of water?
profound hyponatremia.
Name (2) major benefits of exenatide
Exenatide, the GLP-1 agonist, causes weight loss and is not associated with hypoglycemia.
Name the disease: early onset of COPD, bilateral basilar disease (panacinar)
alpha-1-antitrypsin deficiency
Diagnosis of AL
presence of serum or urine monoclonal protein and amyloid deposition on tissue biopsy (abdominal fat pad least invasive)
What are women with DM1 more susceptible to postpartum?
post partum thyrotoxicosis
What other endocrine disorder can cause poorly controlled glucose in DM1 patients post partum?
hyperthyroidism (i.e. post partum thyrotoxicosis)
What happens when a woman is on OCPs and synthroid for hypothyroidism?
Her synthroid dosing requirements may change as estrogen containing medication and increases the TBG.
Name the disease: sensation of dry eyes, ingrown eyelashes, adhesions of the eyelid to the globe.
ocular cicatricial pemphigoid
What do you do when you suspect ocular cicatricial pemphigoid?
conjunctuval biopsy first (treatment with systemic corticosteroids and cyclophosphamide later)
What antibiotic cannot be used with tacrolimus because it also uses the cytochrome P450 system?
erythromycin. would result in tacrolimus toxicity and kidney injury.
Imaging modality of choice when you suspect aortic dissection in someone with poor renal function
TEE - is portable, assess aorta, pericardium, AV, and LV fxn
What disease do you expect when someone who recently used cocaine had terrible chest pain in the back between the shoulder blades, a wide pulse pressure?
aortic dissection
Treatment of Parkinson's disease in a patient <65 years old is...
pramipexole or ropinexole
Name the disease: insideous onset of progressive nonfluent aphasia, semantic dementia...
frontotemporal lobar degeneration
Risk factor management for age-related macular degeneration
stop smoking
Name the disease: drusen (yellow deposits on the retina)
age related macular degeneration
Murmurs that decrease with increased pre-load (stand to squat, passive leg lift, or handgrip) could be:
HCM or mitral valve prolapse.
When a patient is newly diagnosed with primary hyperparathyroidism due to a parathyroid adenoma, what is the next step?
check vitamin D levels, as vitamin D deficiency can mask the severity of primary hyperparathyroidism. Once Vitamin D is repleted, the symptoms may worsen and then the patient may need parathyroidectomy
What are the (4) indications for parathyroidectomy?
Serum calcium > 1 above normal
CrCl <60
T score -2.5 or worse or any previous fracture
age <50
What is the treatment of choice for patients with recurrence of platinum-sensitive ovarian CA who relapse more than 6 months after completion of initial therapy?
another platinum-based chemotherapy regimen.
What do you suspect in a patient post gastric bypass surgery with persistent nausea and vomitting after eating has and how do you evaluate it?
stomal stenosis
endoscopic ultrasound (sometimes barium swallow).
Management of TTP
plasma exchange (stops the platelet consumption that is responsible for the symptoms)
Name the disease:
microangiopathic hemalytic anemia
thrombocytopenia without coagulation disorder
CNS symptos such as headache
TTP
West Nile virus diagnosis can be confirmed by
CSF IgM
What should all old people be screened for?
Depression
Name the disease: pain in the posterior pelvic region while prforming the FABER test with absence of pain on passive hip rotations
sacroilliitis.
How can you reproduce pain with piriformis syndrome?
apply pressure to the sciatic notch
what is the most common cause of bone disease in CKD5 and is associated with PTH <100 and nl alk phos?
adynamic bone disease
What do you do in a patient who has had previous history of UGIB and normal Cscope and EGD?
Repeat EGD first
Management of Barrett's Esophagus when it is first identified
endoscopic and histologic surveillence
What class of anti hypertensives is good to use in the elderly?
HCTZ
Chronic watery diarrhea in a woman in her 60s
microscopic colitis
Management of HSP
steroids
Is there any benefit to using steroids in IPF?
No
Empiric treatment for CSF shunt infection
vanc and cef
Name the type of renal failure: HIV pt with hep C and syphyllis, hypocomplimentemia, dysmorphic erythrocytes, erythrocyte casts...
immune complex-mediated glomerular nephritis
Name the disease:
moderate-to-severe persistent asthma
central bronchiectasis
mucous plugging
increased IgE
eosinophilia
allergic bronchopulmonary aspirgillosis
How do you diagnose suspected allergic bronchopulmonary aspergillosis?
skin test
What medication must be added to standard medical therapy in black patients with Class III or IV heart failure?
ISDN and hydralazine
What do you have to do when someone with UC has high grade dysplasia detected on surveillience colonoscopy?
Total proctocolectomy
Stroke mimicker in a young healthy woman with 30 minutes of paresthesia in her left arm and hand and R sided throbbing headache
migraine with aura
Name the disease: secretory diarrhea in a patient who has had the terminal ileum and ileocecal valve removed from a tumor
bile salt diarrhea - tx with cholestyramine
What antibody test for PBC?
antimitochondrial antibody
Name the disease:
fatigue, pruritis, elevated alk phos
PBC
How do you manage someone with recurrent uric acid stones and a urine pH of 5.5 on UA?
alkalinize the urine with potassium citrate
Name the disease:
hypercoaguable state
pancytopenia
bone marrow aplastic or MDS
PNH (aplastic anemia)
How do you diagnose PNH?
Flow Cytometry shows CD55 and CD59
Name the disease:
mid epigastric pain worse after eating
post prandial diarrhea
elevated fasting glucose
in a man who abuses alcohol
chronic pancreatitis
Diagnosis of chronic pancreatitis
CT scan shows calcifications
When do you test for H. Pylori eradifiction?
When someone has had severe disease (i.e. transfusion requiring hemotphysis, hospitalization) or early stage gastric ca or MALT lymphoma, lastly persistent dyspepsia after test-and-treat
Name the disease:
fever
musculoskeletal symptoms
neuropathies
HTN
proteinuria
hematuria
renal insufficiency
PAN
What (2) drugs are safe to use to treat HTN during pregnacy?
Methyldopa and labetalol
The type of urinary incontinence most frequently gotten by diabetics is:
overflow incontinence from neurogenic bladder - test for it with post void residual
Management of renal failure in hepatorenal syndrome
liver transplant only
What happens to babies born from moms with tet and 22q11.2 deletion?
50% chance of congenital heart disease
How can you tell apart PAN and Takuyasu arthritis?
Taku affects younger women, and their presentation may include claudication, bruits, absence of peripheral pulses
Trouble seeing on a bright sunny day and trouble driving at night with glare of car headlights
cataracts
decreased visual accuity and loss of central vision
perception of straight lines as wavy
macular degeneration
Name the disease:
elderly person with atherosclerotic disease
crampy abdominal pain
bloody diarrhea
ischemic colitis
Management of 1st or 2nd stage syphyllis in a patient with a penicillan allergy
doxycycline (as long as not pregnant)
The best screening test for hearing loss in the elderly, even when they deny having a problem, is
the whispered voice test
Patients with a new diagnosis of MEN 2a should...
undergo a screening for the RET mutation
Name the components of MEN2a
medullary thyroid cancer
hyperparathyroidism
pheochromocytoma
Concominant valve disorder in patients with coarc of the aorta
bicuspid aortic valve - be wary for AV stenosis or AVR
Name the disease:
wide pulse pressure
rapidly collapsing pulse
pulsing nailbeds
brief systolic and long diastolic murmur
LV enlargement
severe aortic regurgitation
name the disease:
neurosurgery patient
hyponatremia
increased urine Na excretion
hypovolemia
increased urine concentration
cerebral salt wasting
How can you distinguish cerebral salt wasting from SIADH?
hypotension is usually only present in cerebral salt wasting
Which aortic valve replacement patients do not need a heparin bridge perioperatively?
low risk patient
aortic valve (not mitral)
no history of thromboembolism
no LV dysfunction, no AFib, hypercoagulable condition)
Management of resistant HTN in a pt not controlled on 3 bp agents already - what is good to add?
Spironolactone
Treatment of herpes zoster not involving the eye
oral valacyclovir or famcyclovir
Treatment of early stage HER2+ breast cancer with adjuvent:
trastuzumab (herceptin) but know the generic
Treatment of post-MI pericarditis (Dressler syndrome)
high dose aspirin preferred over NSAIDs
Severe Needlestick injury from an HIV and Hep C positive pt
take 3 antiretrovirals immediately. no hep c prophylaxis
What should a primary care physician check in all obese pts with BMI between 25-24.9?
a waist circumference
Management of ascending aortic atheroma >4mm
antiplatelet
or
antithrombotic therapy (i.e. warfarin)
When you discover pulmonary HTN in a patient you also suspect my have OSA what is the first next step?
sleep study because it is less invasive and may be a reversible secondary cause to the pulm htn
What is one of the hepatic side effects of interferon?
it can cause autoimmune hepatitis - stop interferon or ribaviron in a hep c pt whose LFTs go up
What is the next step in a patient with gallstone pancreatitis and likely biliary obstruction?
ERCP - with sphincterotomy and stone removal
In a HCV cirrhotic with diuretic resistant ascites, what is the next step?
liver transplant referral (TIPS can be associated with high morbidity in advanced cirrhosis)
What is the next step in a patient with newly discovered cirrhosis?
EGD screening for varices first before medical therapy is started.
What is the next step with a bleeding stomach ulcer refractory to medical and endoscopic therapy?
surgical repair. No role for octreotide that we know of once endoscopic therapy has been instituted.
Treatment for early stage PBC
ursodeoxycholic acid
Diagnosis of iron deficiency in CKD patients not yet on dialysis:
ferritin < 100
AND
transferrin sat < 20%