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28 Cards in this Set

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 Kell K=k+ K+k= K+k+ Kp(a+b=) Kp(a=b+) Kp(a+b+) Js(a+b=) Js(a=b+) Js(a+b+) Duffy Fy(a+b=) Fy(a=b+) Fy(a+b+) Fy(a=b=) Kidd Jk(a+b=) Jk(a=b+) Jk(a+b+) Jk(a=b=) Lutheran Lu(a+b=) Lu(a=b+) Lu(a+b+) Lu(a=b=) Ii "i-cord' "I-adult" "i-adult" "I-cord" P P1 P2 P1k P2k p MNS MM MN NN SS Ss ss U neg Roughly what % or the population has the "M" antigen? About 75% 78% white 70% black What % of the population has the "s" antigen? 89% white 97% black How difficult would it be to find compatible cells for someone with an ANti-m? It would be relatively easy because a great portion of the population has the M antigen; then, approximately 25% would be compatable. 1 in 4 units would be compatable How difficult would it be fto find compatible cells for someone with an Anti-s? Pretty difficult because only 10% of the white and 3% fo the black population lacks this antigen. only 1 in 10 units would be compatible. Which of the P blood group antigens are "high-frequency" antigens? P, and Pk Which P group antibody would you expect to find most frequently in the clinical lab? Anti-P1 What is Donath Landsteiner and why is it called an autoantibody? Anti-P antibody, hemolytic IgG that usually is encountered in patients with Paroxysmal Cold Hemoglobinuria (PCH). It is called an autoantibody, because it turns into an antibody for a self-antigen. IgG autoanti-P binds to P positive RBC's and activates complement at low temperatures, causing hemolysis to occur at warmer temps. Would you expect Anti-I to be a cause of HDN? No, IgM's cannot cross the placenta and newborns are I neg Why are antibodies to k, Kpb and Jsb rarely found? These are high frequency antigens; the corresponding antibody will be rarely found Why is it uncommon to find antibodies to Kpa and Jsa? These antigens are co-dominant alleles on closely linked loci with Kpb and Jsb; they produce low frequencies. Would it be difficult to find donor cells for a patient with Anti-Kpa and Anti-Jsa? No, it would be easy; donor units possessing these antigens are uncommon. How common is the Lub antigen? 100% of the population have this antigen Name 2 reasons why anti-Lua is not associated with HDN. -IgM -poorly developed at birth List the blood groups that would show stronger reactions following enzyme treatment. -Kidd -P -Ii -Lewis -Rh(not D) List the blood groups that would show weaker or missing reactions following enzyme treatment. -Duffy -Xga -MN List the blood groups that would show no change following enzyme treatment. -Lutheran -Kell -'D' What blood groups show variable reactivity following enzyme treatment. -S -s -U -IgG -Produced in response to antigen exposure -Ab agglutinate optimally in IAT -Ab do not bind complement -TRX/HDN -Anti-K is the most common antibody Kell blood group -Agglutination reactions are best observed in IAT -Antibodies do not bind complement -TRX -Can show dosage -Anti-Fya is more common than anti-Fyb Duffy blood group -Does show dosage -Binds complement -Produced through antigen exposure -Antibodies do not store well -Phenotype frequencies tend to vary among the population. Kidd blood group Can be present without RBC stimulation -IgM and IgG -Has characteristic mixed-field pattern of agglutination -Mild cases of HDN Anti-Lua